Brain Tumor Drug Development provides a clear, multidisciplinary update on modern therapies for glioblastoma and other aggressive brain tumors. The book focuses on improving drug precision, crossing the blood-brain barrier, identifying biomarkers, designing effective trials, and accelerating translation from research to real patient care. Key Features Discusses how to overcome the blood-brain barrier using advanced delivery methods Explains how to improve drug penetration and specificity with nano and polymer-based systems Explores new therapies through immunotherapy, gene therapy, and personalised medicine Outlines preclinical models and identifies biomarkers to support clinical success Details regulatory-aligned clinical trial strategies for faster translation

The Role of Asymmetric Synthesis in Drug Discovery presents a comprehensive overview of how enantioselective synthesis drives the development of safer, more effective therapeutics. Because the 3D arrangement of atoms profoundly affects a drug's activity, efficacy, and safety, asymmetric synthesis enables the precise production of single enantiomers-minimizing side effects and maximizing therapeutic performance. In the era of precision medicine, this selective control is indispensable for designing molecules that interact optimally with biological targets. Spanning ten chapters, the book highlights cutting-edge experimental research on the asymmetric synthesis of diverse bioactive heterocycles. Topics include foundational principles of enantioselective synthesis, chiral heterocycles, alkaloids, terpenoids, spirooxindoles, dihydropyrimidinones, piperazine derivatives, and asymmetric oxazines. Additional chapters explore chiral triazoles, benzimidazoles, and broader classes of chiral pharmaceuticals synthesized through asymmetric strategies. Together, these chapters illustrate both the scientific depth and therapeutic potential of modern asymmetric methodologies. The book serves as a forward-looking resource designed to inspire new research on chiral heterocycles and to support ongoing efforts in medicinal chemistry and drug design. Key Features: Explores core principles of enantioselective and asymmetric synthesis in drug discovery. Highlights synthetic strategies for diverse bioactive chiral heterocycles and natural products. Showcases experimental advancements in the synthesis of alkaloids, terpenoids, spirooxindoles, and more. Examines green, modern, and emerging approaches to asymmetric synthesis. Demonstrates therapeutic relevance through biological evaluations and pharmaceutical applications. Inspires future research on novel chiral scaffolds for drug development.

Brain Tumour Drug Development provides a clear, multidisciplinary update on modern therapies for glioblastoma and other aggressive brain tumours. The book focuses on improving drug precision, crossing the blood-brain barrier, identifying biomarkers, designing effective trials, and accelerating translation from research to real patient care. Key Features Overcomes the blood-brain barrier using advanced delivery methods Improves drug penetration & specificity with nano and polymer-based systems Explores new therapies through immunotherapy, gene therapy, and personalised medicine Builds preclinical models & identifies biomarkers to support clinical success Designs regulatory-aligned clinical trial strategies for faster translation

Handbook of Practical Pharmacology – I serves as a vital bridge between theoretical pharmacology and laboratory application, equipping learners with the experimental skills essential to understanding drug actions through hands-on animal studies. A comprehensive, curriculum-based guide designed for second-year B. Pharm. students, fully aligned with the Pharmacy Council of India’s 2014 regulations. The book introduces students to fundamental laboratory concepts, animal handling as per CCSEA guidelines, drug administration routes, and experimental models like Rotarod, Actophotometer, and rabbit eye studies. It explores pharmacodynamic responses to various classes of drugs, including hepatic enzyme inducers, skeletal muscle relaxants, anticonvulsants, and anxiolytics. Each chapter combines clarity, precision, and ethical awareness, ensuring reproducibility and adherence to professional standards. Serving both as a laboratory manual and a learning companion, this handbook enhances analytical thinking and experimental competence, helping students gain a deeper, practice-based understanding of pharmacology. Key Features · Aligns with the PCI 2014 syllabus for second-year B. Pharm. students. · Explains fundamental experimental pharmacology concepts and instrumentation. · Demonstrates animal handling and drug administration techniques per CCSEA guidelines. · Guides pharmacodynamic testing using established models like Rotarod, Actophotometer, and MES. · Promotes laboratory competence, ethical compliance, and analytical reasoning in pharmacology

Drug Repurposing for Antivirals is a timely volume bridging pharmacology, virology, and computational science to present a cohesive understanding of the scientific and translational potential of drug repurposing in antiviral therapy with innovative strategies of finding new antiviral applications for existing drugs, an approach that shortens development timelines, reduces costs, and accelerates clinical deployment The book covers core concepts, from historical successes to modern applications in combating viral diseases. It explores computational screening, molecular docking, and AI-driven tools for identifying candidate molecules; experimental validation methods; and real-world case studies involving influenza, SARS-CoV-2, HIV, and hepatitis viruses. Special focus is given to host-targeted antivirals, broad-spectrum agents, and strategies to counter viral resistance. Regulatory aspects, challenges, and future directions for integrating repurposed antivirals into clinical practice are also discussed. Key Features: Integrates theory, methodology, and real-world case studies. Covers both computational and experimental approaches. Highlights implications for pandemic preparedness and rapid-response drug discovery. Includes contributions from leading experts in virology, medicinal chemistry, and pharmacology.

New Drugs Targeting Antibiotic-Resistant Bacteria: Recent Advances examines the molecular, pharmacological, and clinical dimensions of resistance development and highlights innovative therapeutic approaches aimed at overcoming multidrug-resistant organisms (MDROs), providing an in-depth exploration of emerging strategies to combat one of the most urgent public health challenges of our time—antimicrobial resistance (AMR). Beginning with the mechanisms underlying bacterial resistance such as β-lactamase production, efflux pump activity, and membrane protein modification, the text underscores the growing threat posed by ESKAPE pathogens and CDC-classified priority infections. Chapters also explore cutting-edge interventions including bacteriophage therapy, discovery of novel antibacterial compounds from natural sources, and the use of nanoparticles and quorum-sensing inhibitors to suppress bacterial virulence. Further sections discuss carbapenemase-mediated resistance, emphasizing enzyme classification, detection strategies, and the importance of clinical microbiology in guiding antibiotic stewardship. By integrating one-health perspectives that consider human, animal, and environmental dimensions, this book presents a holistic roadmap for addressing resistance evolution through innovation and responsible antibiotic use. Key Features Examines the molecular mechanisms driving antibiotic resistance in key bacterial species Explores bacteriophage therapy as a promising alternative to conventional antimicrobials Discovers natural-source compounds and novel drug leads for future antibiotic development Analyses carbapenemase-mediated resistance and clinical detection techniques Evaluates new therapeutic approaches including nanoparticle-based treatments and quorum-sensing inhibition Promotes the one-health approach to tackling multidrug-resistant organisms globally

Technical Advances in Pharmacy: An Overview examines the convergence of digital transformation, automation, and data intelligence in revolutionizing drug discovery, formulation, and healthcare delivery Across twelve in-depth chapters the book presents a forward-looking exploration of how emerging technologies are reshaping the landscape of pharmaceutical sciences. The book also covers cutting-edge developments such as artificial intelligence in drug discovery, pharmacogenomics and personalized medicine, blockchain in pharmaceutical supply chains, 3D printing of dosage forms, tele pharmacy, data analytics, and automation in pharmacy practice. By integrating computational modelling with experimental techniques, the text highlights the translational potential of modern technologies in enhancing drug development, patient adherence, and clinical outcomes. Serving as both a reference and a roadmap, this volume bridges traditional pharmaceutical foundations with next-generation innovations, offering readers an insightful perspective on the technological evolution shaping the future of pharmacy. Key Features Examines the role of artificial intelligence, pharmacogenomics, and data analytics in modern drug discovery. Explores blockchain, automation, and robotics as enablers of efficient and transparent pharmacy systems. Integrates computational modeling with experimental approaches for enhanced drug formulation and testing. Highlights 3D printing, telepharmacy, and RegTech as transformative tools in pharmaceutical innovation. Bridges classical pharmaceutical sciences with emerging digital and biotechnological advancements.

A fascinating exploration of widely used medicinal and culinary plants that straddle the line between healing and harm. Poison or Remedy? Case Reports on Selected Plants presents detailed botanical and phytochemical insights, highlighting the active compounds responsible for both therapeutic and toxic effects. The book draws on real-world cases from across the globe to examine how plant parts and preparations that are often used for health, culinary, or traditional purposes can lead to adverse outcomes when misused or misunderstood. Featured plants include celery and Heracleum species with phototoxic effects, cinnamon rich in coumarins, tropane alkaloid-containing Angel's Trumpet, colchicine-bearing Gloriosa and Colchicum, licorice, ivy, nutmeg, oleander, Syrian rue, rhododendron (mad honey), and the castor oil plant. Through these examples, the book underscores the delicate balance between medicinal potential and toxic risk. Key Features: - Explores the dual nature of medicinal plants through global case reports. - Presents phytochemical structures of key bioactive and toxic compounds. - Highlights real-world implications of plant misuse in food, medicine, and cosmetics. - Combines scientific accuracy with readability for both experts and general readers. - Promotes awareness of plant safety, regulation, and responsible usage.

A multidisciplinary exploration of quinones as a vital structural class in medicinal chemistry Drawing from both natural and synthetic sources, the book explores the structural diversity, reactivity, and therapeutic potential of quinone compounds, positioning them as privileged moieties in the development of pharmacologically active agents. The text covers essential themes such as synthesis strategies, identification techniques, biochemical relevance, and pharmacodynamics of quinones and their derivatives. It delves into their traditional use in medicine, contemporary roles in treating diseases like cancer and infections, and their capacity to interact with multiple biological targets. Specific chapters discuss glyco hybrids, ROS generation, enzymatic pathways, and toxicity profiles, offering a comprehensive overview of their medicinal versatility. Key features: Explores synthesis and structural modification techniques Analyzes biochemical and pharmacodynamic mechanisms Reviews traditional and modern therapeutic uses Examines toxicity concerns and safety profiles Highlights marketed drugs and emerging candidates Presents recent studies and future trends.

Bridging the fields of pharmacy, biotechnology, dermatology, and cosmetic science, this book offers a multidisciplinary perspective on innovation, efficacy, and safety in the development of next-generation beauty and personal care products. The book discusses emerging technologies such as nanoformulations, artificial intelligence, gene therapy, personalized medicine, and peptide science. It addresses their transformative role in cosmetic product development-from skin and hair care to sun protection, anti-aging solutions, and mood-enhancing formulations. Readers will also gain insights into regulatory frameworks, clinical studies, and intellectual property considerations, making this a practical guide for both innovation and compliance in the beauty-tech space. Key Features: Explores integration of pharmaceutical techniques in cosmetic formulation Highlights nano-carriers, AI tools, and gene-based therapies in product development Details the role of natural and herbal ingredients in modern skin and hair care Covers peptide technologies for anti-aging and skin rejuvenation Addresses personalized medicine and pharmacogenomics in cosmetics Reviews regulatory challenges, clinical validation, and patent strategies