In Silico Modelling and Simulation for Diabetes Therapy is an exploratory study positioned at the intersection of pharmacology, systems biology, and biomedical engineering. The book demonstrates how in silico approaches support a better understanding of diabetes pathophysiology, insulin kinetics, and drug–receptor interactions while reducing reliance on costly, time-intensive clinical trials.

The book begins with core concepts of in silico modelling before examining mechanisms of diabetes and existing care technologies, such as glucose monitoring systems, insulin pumps, artificial pancreas systems, and closed-loop control algorithms. It provides practical coverage of computational tools, including MATLAB, Simulink, COPASI, and Cell Designer, supported by case studies on insulin dosing, therapy optimisation, and data-driven modelling. Ethical, regulatory, and patient privacy considerations are discussed alongside emerging trends such as AI-driven modelling, virtual clinical trials, and personalised diabetes management.

Key Features:

Explains in silico modelling principles for diabetes research and therapy design

Provides integrated disease mechanisms, insulin kinetics, and drug–receptor interactions

Real-world case studies demonstrating the practical use of computational tools

Addresses regulatory, ethical, and data privacy considerations in digital health

Highlights future directions, including AI and personalised diabetes care

The Role of Nutraceuticals in Degenerative Diseases provides a comprehensive overview of the growing role of nutraceuticals in preventing and managing degenerative disorders. As awareness of dietary supplements as supportive therapy increases, this book examines how nutraceuticals can complement conventional treatments in slowing cellular degeneration and improving quality of life. The book systematically explains the causes, mechanisms, and therapeutic approaches of major degenerative diseases, including respiratory, neurodegenerative, cardiovascular, musculoskeletal, renal, hepatic, ophthalmic, and metabolic disorders. It covers both foundational concepts of nutraceuticals and disease pathology, along with disease-specific applications supported by mechanistic insights and emerging research. Topics such as in silico identification of nutraceuticals, biomarkers, and prevention strategies are also discussed, offering a balanced view of theory and practice. Key Features; -Explains fundamentals, scope, and identification of nutraceuticals -Describes mechanisms and progression of major degenerative diseases -Examines disease-specific nutraceutical interventions across organ systems -Integrates conventional therapy with dietary and preventive strategies -Highlights emerging research, biomarkers, and preventive approaches

With the global rise in use of herbal medicine alongside conventional drugs, understanding the interactions between them has become critical to ensuring therapeutic effectiveness and patient safety. Herb-Drug Interactions: A Medicinal Approach integrates traditional knowledge, modern pharmacology, and computational tools to provide a holistic perspective on herb-drug interactions. The book covers the historical evolution of herbal medicine, chemistry and mechanisms of herb-drug interactions, pharmacodynamics in metabolic diseases, and clinical implications. It also explores transport mechanisms, healthcare applications, and advanced computational approaches, including databases and bioinformatics tools. Special attention is given to vulnerable populations such as children, the elderly, and pregnant women, offering practical clinical insights. By combining mechanistic understanding with real-world applications, the book serves as both a reference and a guide for advancing safe, evidence-based integrative healthcare. Key Features - Integrates traditional herbal knowledge with modern pharmacology and computational approaches. - Explains mechanisms, pharmacodynamics, and clinical implications of herb-drug interactions. - Highlights therapeutic potential, drug-herb synergy, and safety considerations. - Focuses on vulnerable populations: paediatrics, geriatrics, and pregnancy. - Provides practical guidance for evidence-based integrative healthcare.

The Role of Nutraceuticals in Degenerative Diseases provides a comprehensive overview of the growing role of nutraceuticals in preventing and managing degenerative disorders. As awareness increases around dietary supplements as supportive therapy, this book examines how nutraceuticals can complement conventional treatments in slowing cellular degeneration and improving quality of life. The book systematically explains the causes, mechanisms, and therapeutic approaches of major degenerative diseases, including respiratory, neurodegenerative, cardiovascular, musculoskeletal, renal, hepatic, ophthalmic, and metabolic disorders. It covers both foundational concepts of nutraceuticals and disease pathology, along with disease-specific applications supported by mechanistic insights and emerging research. Topics such as in silico identification of nutraceuticals, biomarkers, and prevention strategies are also discussed, offering a balanced view of theory and practice. Key Features Explains fundamentals, scope, and identification of nutraceuticals Describes mechanisms and progression of major degenerative diseases Examines disease-specific nutraceutical interventions across organ systems Integrates conventional therapy with dietary and preventive strategies Highlights emerging research, biomarkers, and preventive approaches.

Brain Tumor Drug Development provides a clear, multidisciplinary update on modern therapies for glioblastoma and other aggressive brain tumors. The book focuses on improving drug precision, crossing the blood-brain barrier, identifying biomarkers, designing effective trials, and accelerating translation from research to real patient care. Key Features Discusses how to overcome the blood-brain barrier using advanced delivery methods Explains how to improve drug penetration and specificity with nano and polymer-based systems Explores new therapies through immunotherapy, gene therapy, and personalised medicine Outlines preclinical models and identifies biomarkers to support clinical success Details regulatory-aligned clinical trial strategies for faster translation

The Role of Asymmetric Synthesis in Drug Discovery presents a comprehensive overview of how enantioselective synthesis drives the development of safer, more effective therapeutics. Because the 3D arrangement of atoms profoundly affects a drug's activity, efficacy, and safety, asymmetric synthesis enables the precise production of single enantiomers-minimizing side effects and maximizing therapeutic performance. In the era of precision medicine, this selective control is indispensable for designing molecules that interact optimally with biological targets. Spanning ten chapters, the book highlights cutting-edge experimental research on the asymmetric synthesis of diverse bioactive heterocycles. Topics include foundational principles of enantioselective synthesis, chiral heterocycles, alkaloids, terpenoids, spirooxindoles, dihydropyrimidinones, piperazine derivatives, and asymmetric oxazines. Additional chapters explore chiral triazoles, benzimidazoles, and broader classes of chiral pharmaceuticals synthesized through asymmetric strategies. Together, these chapters illustrate both the scientific depth and therapeutic potential of modern asymmetric methodologies. The book serves as a forward-looking resource designed to inspire new research on chiral heterocycles and to support ongoing efforts in medicinal chemistry and drug design. Key Features: Explores core principles of enantioselective and asymmetric synthesis in drug discovery. Highlights synthetic strategies for diverse bioactive chiral heterocycles and natural products. Showcases experimental advancements in the synthesis of alkaloids, terpenoids, spirooxindoles, and more. Examines green, modern, and emerging approaches to asymmetric synthesis. Demonstrates therapeutic relevance through biological evaluations and pharmaceutical applications. Inspires future research on novel chiral scaffolds for drug development.

Brain Tumour Drug Development provides a clear, multidisciplinary update on modern therapies for glioblastoma and other aggressive brain tumours. The book focuses on improving drug precision, crossing the blood-brain barrier, identifying biomarkers, designing effective trials, and accelerating translation from research to real patient care. Key Features Overcomes the blood-brain barrier using advanced delivery methods Improves drug penetration & specificity with nano and polymer-based systems Explores new therapies through immunotherapy, gene therapy, and personalised medicine Builds preclinical models & identifies biomarkers to support clinical success Designs regulatory-aligned clinical trial strategies for faster translation

Handbook of Practical Pharmacology – I serves as a vital bridge between theoretical pharmacology and laboratory application, equipping learners with the experimental skills essential to understanding drug actions through hands-on animal studies. A comprehensive, curriculum-based guide designed for second-year B. Pharm. students, fully aligned with the Pharmacy Council of India’s 2014 regulations. The book introduces students to fundamental laboratory concepts, animal handling as per CCSEA guidelines, drug administration routes, and experimental models like Rotarod, Actophotometer, and rabbit eye studies. It explores pharmacodynamic responses to various classes of drugs, including hepatic enzyme inducers, skeletal muscle relaxants, anticonvulsants, and anxiolytics. Each chapter combines clarity, precision, and ethical awareness, ensuring reproducibility and adherence to professional standards. Serving both as a laboratory manual and a learning companion, this handbook enhances analytical thinking and experimental competence, helping students gain a deeper, practice-based understanding of pharmacology. Key Features · Aligns with the PCI 2014 syllabus for second-year B. Pharm. students. · Explains fundamental experimental pharmacology concepts and instrumentation. · Demonstrates animal handling and drug administration techniques per CCSEA guidelines. · Guides pharmacodynamic testing using established models like Rotarod, Actophotometer, and MES. · Promotes laboratory competence, ethical compliance, and analytical reasoning in pharmacology

Drug Repurposing for Antivirals is a timely volume bridging pharmacology, virology, and computational science to present a cohesive understanding of the scientific and translational potential of drug repurposing in antiviral therapy with innovative strategies of finding new antiviral applications for existing drugs, an approach that shortens development timelines, reduces costs, and accelerates clinical deployment The book covers core concepts, from historical successes to modern applications in combating viral diseases. It explores computational screening, molecular docking, and AI-driven tools for identifying candidate molecules; experimental validation methods; and real-world case studies involving influenza, SARS-CoV-2, HIV, and hepatitis viruses. Special focus is given to host-targeted antivirals, broad-spectrum agents, and strategies to counter viral resistance. Regulatory aspects, challenges, and future directions for integrating repurposed antivirals into clinical practice are also discussed. Key Features: Integrates theory, methodology, and real-world case studies. Covers both computational and experimental approaches. Highlights implications for pandemic preparedness and rapid-response drug discovery. Includes contributions from leading experts in virology, medicinal chemistry, and pharmacology.

New Drugs Targeting Antibiotic-Resistant Bacteria: Recent Advances examines the molecular, pharmacological, and clinical dimensions of resistance development and highlights innovative therapeutic approaches aimed at overcoming multidrug-resistant organisms (MDROs), providing an in-depth exploration of emerging strategies to combat one of the most urgent public health challenges of our time—antimicrobial resistance (AMR). Beginning with the mechanisms underlying bacterial resistance such as β-lactamase production, efflux pump activity, and membrane protein modification, the text underscores the growing threat posed by ESKAPE pathogens and CDC-classified priority infections. Chapters also explore cutting-edge interventions including bacteriophage therapy, discovery of novel antibacterial compounds from natural sources, and the use of nanoparticles and quorum-sensing inhibitors to suppress bacterial virulence. Further sections discuss carbapenemase-mediated resistance, emphasizing enzyme classification, detection strategies, and the importance of clinical microbiology in guiding antibiotic stewardship. By integrating one-health perspectives that consider human, animal, and environmental dimensions, this book presents a holistic roadmap for addressing resistance evolution through innovation and responsible antibiotic use. Key Features Examines the molecular mechanisms driving antibiotic resistance in key bacterial species Explores bacteriophage therapy as a promising alternative to conventional antimicrobials Discovers natural-source compounds and novel drug leads for future antibiotic development Analyses carbapenemase-mediated resistance and clinical detection techniques Evaluates new therapeutic approaches including nanoparticle-based treatments and quorum-sensing inhibition Promotes the one-health approach to tackling multidrug-resistant organisms globally