Research Protocols for Ophthalmic Disease Mechanisms and Therapeutics: Glaucoma – Ocular Hypertension offers a detailed, step-by-step protocols for isolating, characterizing, and analyzing cells and tissues of the eye's anterior segment—where OHT originates—using techniques from molecular biology, pharmacology, and histology. Across eight thematic sections, the book covers ocular anatomy, drug screening, receptor localization, cell-based assays, in vitro and in vivo models, drug formulation, and cutting-edge technologies such as gene editing, single-cell RNA sequencing, and stem cell therapies. Each protocol is designed to support reproducibility and translational relevance. Key Features: Details validated protocols for drug discovery and disease modeling Demonstrates methods for studying receptor function and pharmacokinetics Provides animal models and ex vivo systems to evaluate therapeutic strategies Incorporates emerging tools such as CRISPR, metabolomics, and exosomes Bridges experimental design with clinical relevance for glaucoma research

With renal dysfunction affecting millions worldwide, this book presents a timely and integrative look at emerging insights—from molecular foundations to clinical management. It explores the intricate mechanisms, systemic impact, and clinical complexities of kidney diseases in a multidisciplinary context. Spanning a broad spectrum of conditions, the book addresses renal tubular acidosis, polycystic kidney disease, renal lithiasis, diabetic kidney disease, and sodium imbalance–linked hypertension. Chapters delve into nephrotoxicity, loss of cellular identity in renal carcinoma, epigenetics, dysbiosis, and the evolving role of SGLT2 inhibitors. The book also highlights innovative approaches such as stem cell therapy and the systemic immune interactions that underlie chronic kidney injury. Key Features: Examines genetic and epigenetic underpinnings of renal disease Explores microbiota and immune system crosstalk in kidney pathology Discusses both acute and chronic conditions with clinical relevance Integrates foundational science with translational perspectives Includes emerging therapies and precision medicine approaches

Zebrafish Models for Experimental Pharmacology: A Handbook is an essential resource for researchers, pharmacologists, and students exploring the expanding role of Zebrafish in drug discovery and experimental pharmacology. The book presents a clear, practical guide to contemporary experimental designs, ethical considerations, animal care, and laboratory techniques specific to Zebrafish models. Key features Comprehensive coverage of drug administration routes, blood collection, and anesthesia techniques in Zebrafish Detailed methodologies for a wide range of behavioral and pharmacological assays, including the Shoaling Test, Novel Diving Tank Test, T-Maze, Y-Maze, Light-Dark Chamber Test, and more Practical guidance on experimental preparation, solution formulation, and tissue handling for in vitro studies Examples and illustrated explanations to support practical implementation in laboratory settings Designed to bridge the gap between foundational research and translational applications, this handbook is a valuable reference for postgraduate students, research scholars, and professionals working in academic, clinical, and industrial pharmacology settings.

Introduction: Antibiotics and Reproductive Health explores the intricate interplay between antibiotics and the female reproductive system. This comprehensive volume offers an evidence-based analysis of how antibiotics impact fertility, pregnancy, and breastfeeding, with a special focus on antibiotic resistance and emerging treatment alternatives. Bridging medicine, pharmacology, and reproductive health, the book is structured into nine chapters covering topics from the mechanism of antibiotics in reproductive health to alternative therapies like probiotics and herbal medicine. It provides clinical guidelines and discusses risks such as antibiotic resistance and microbiome disruption. Key Features: - Detailed exploration of antibiotic mechanisms in reproductive health. - Discussion on risks including antibiotic resistance and hormonal effects. - Examination of alternative therapies like probiotics and herbal medicine. - Clinical guidelines for antibiotic use in reproductive health.

Spinal Surgery Biomechanics: Principles for Residents and Students provides a comprehensive overview of the biomechanical principles essential for understanding spinal surgery techniques. This book explores key topics, including pedicle screw anchorage, lumbar total disc replacement, interbody fusion techniques, and spinal surgery in osteoporotic patients. It also covers degenerative spondylolisthesis, interspinous devices, and spinal stability classification systems. Written for students, residents, and researchers, this volume simplifies complex biomechanical concepts with clear explanations, clinical insights, and up-to-date research findings. Key Features: - Covers essential biomechanics relevant to spinal surgery procedures. - Discusses surgical approaches, implant selection, and stability mechanisms. - Examines spine surgery in osteoporotic and degenerative conditions. - Explores motion-preserving and fusion-based spinal implants. - Reviews classification systems for spinal trauma and instability.

Promising Cancer Therapeutic Drug Targets: Recent Advancements offers a comprehensive overview of novel and emerging strategies in cancer therapy. The book explores cutting-edge approaches such as exosomal delivery systems, CRISPR/Cas9 gene editing, and immunotoxins, alongside targeting mechanisms like cancer stem cells, apoptosis pathways, and key signaling processes. A strong emphasis is placed on the therapeutic potential of natural compounds in disrupting cancer progression and enhancing treatment response. Chapters are organized around molecular targets, therapeutic pathways, and bioactive agents to provide a clear, thematic structure. Key Features - In-depth exploration of CRISPR/Cas9, exosomes, and stem cell-targeted therapy - Focus on natural compounds in cancer treatment - Insights into key signaling pathways (Hippo, Hedgehog, STAT3) - Discussion on apoptosis and drug resistance mechanisms.

Bioactive Compounds Targeting Neurodegenerative Diseases explores the therapeutic potential of natural bioactive compounds in preventing and managing neurodegenerative disorders such as Alzheimer's, Parkinson’s, and Huntington’s disease. The book integrates insights from neuroscience, pharmacognosy, and nanotechnology to highlight innovative strategies for drug delivery and treatment. Chapters cover plant-based bioactives, advanced nano-carriers, intranasal administration, and blood-brain barrier targeting. It also discusses clinical approaches, current treatment challenges, and intellectual property considerations. Key Features: - Comprehensive overview of natural bioactive compounds in neurodegenerative therapy. - Coverage of phytochemicals, nano-delivery systems, and intranasal administration. - Insights into the blood-brain barrier and clinical management strategies. - Discussion on current therapies and intellectual property issues.

Bentham Briefs in Biomedicine and Pharmacotherapy (Volume 3): Anthraquinones: Bioactive Multifaceted Therapeutic Agents discusses the expansive realm of anthraquinones, pivotal aromatic compounds in medicine, biotechnology, and industry. This comprehensive volume integrates traditional knowledge with cutting-edge research, covering biosynthesis, analytical methodologies, therapeutic applications, and industrial uses. Key Features: - Detailed exploration of anthraquinone biosynthesis and bioactivity. - Advanced insights into nanotechnology-driven drug delivery. - Modern extraction techniques and analytical methodologies. - Contributions from leading experts, ensuring rigorous, research-driven content.

Therapeutic Plants: Recent Advances in the Use of Herbs as Alternative Medications offers an in-depth exploration of how herbs are reshaping modern healthcare. Bridging traditional knowledge and scientific innovation, the book highlights the therapeutic power of medicinal plants in managing chronic diseases like diabetes, cancer, and cardiovascular disorders. It explores bioactive compounds, Ayurvedic principles, and advanced drug delivery systems, including nanoparticles. Chapters cover disease-specific applications, plant-based drug discovery, and the role of metabolomics and in-silico methods in drug design. The book also features detailed studies on specific herbs like Barleria longiflora, Terminalia chebula, and Lawsonia inermis. Key Features: - Scientific insights into herbal treatments for chronic diseases. - Integration of traditional and modern medicine. - Innovative delivery systems, including nanotechnology. - In-silico drug design and metabolomics applications. - Case studies of medicinal plants and their bioactive compounds.

Gut Microbiota and their Impact on Disease Pathways and Interventions discusses the intricate world of gut microbiota and its profound influence on human health and disease. This comprehensive volume explores the microbiome's pivotal role in conditions ranging from obesity and cardiovascular disease to inflammatory bowel disease, diabetes, ocular diseases, and neurological disorders. It offers cutting-edge insights into therapeutic strategies such as probiotics, prebiotics, and fecal microbiota transplantation, alongside emerging approaches like gut microbial metabolites as diagnostic biomarkers. It serves as a vital resource for understanding and harnessing the role of gut health in disease prevention and management. Key Features: - Multidisciplinary approach integrating microbiology, medicine, and biotechnology. - Innovative treatment modalities including personalized medicine based on microbiome analysis. - Exploration of gut-brain, gut-heart, and gut-immune system interactions.