Chemistry of Bipyrazoles: Synthesis and Applications covers the synthetic pathways for all types of bipyrazoles. 5 chapters cover bipyrazole systems, N,N- and N,C-bipyrazoles, namely 1,1`-bipyrazole, 1,3`-bipyrazole, 1,4`-bipyrazole, 3,3`-bipyrazoles, 3,4`-bipyrazoles and 4,4`-bipyrazoles The contents explain several types of reactions: 1) condensation reactions of hydrazines with tetracarbonyls, dihydroxydicarbonyl compounds or pyrazole-based difunctional compounds; 2) 1,3-dipolar cycloaddition of pyrazole-based hydrazonoyl halides with activated methylene compounds; 3) metal catalyzed cross-coupling reactions. The book concludes with a chapter that details the applications of bipyrazole derivatives in different industries. Information about advanced concepts used in chemical engineering such as metal-organic frameworks (MOFs) and corrosion inhibition are highlighted. The book contents are presented in an easy-to-understand manner suitable for readers in organic chemistry at senior levels of education and industry expertise. Each chapter is supplemented with detailed references.

Frontiers in Cardiovascular Drug Discovery is a book series devoted to publishing the latest advances in cardiovascular drug design and discovery. Each volume brings reviews on the biochemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships of molecules used in cardiovascular therapy. The book series should prove to be of great interest to all medicinal chemists and pharmaceutical scientists involved in preclinical and clinical research in cardiology. Volume 6 covers the following topics: - Cardiovascular effects of ranolazine and the scope for translational research: a current review of literature - Rho/Rho kinase signaling pathway and disease: - Hibernation or transformation? Challenges in cardiovascular drug development - New approaches in P2Y12 receptor blocker drugs use - Pathophysiological links between diabetes and cardiovascular diseases: at the biochemical and molecular levels

Frontiers in Natural Product Chemistry is a book series devoted to publishing monographs that highlight important advances in natural product chemistry. The series covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds, including research on natural substances derived from plants, microbes and animals. Reviews of structure elucidation, biological activity, organic and experimental synthesis of natural products as well as developments of new methods are also included in the series. Volume nine of the series brings together 7 reviews on a variety of natural products and sources along with a chapter on the basics of investigating antioxidant activity. Propolis and its key chemical constituents: a promising natural product in therapeutic applications Investigation of the effects of using omega-3 fatty acids on egg quality in functional egg production Quercetin, a flavonoid with remarkable anticancer activity Swertiamarin for the treatment of metabolic syndrome Overview of traditional uses, phytochemistry and pharmacology of Peganum harmala l. Investigation of measurement methods of antioxidant activity and involved mechanisms Recent progress on natural and synthetic flavanone and its derivatives Role of virgin coconut oil as a multiple health promoting functional oil

Advances in Organic Synthesis is a book series devoted to the latest advances in synthetic approaches towards challenging structures. The series presents comprehensive reviews written by eminent authorities on different synthetic approaches to selected target molecules and new methods developed to achieve specific synthetic transformations or optimal product yields. Advances in Organic Synthesis is essential for all organic chemists in academia and the industry who wish to keep abreast of rapid and important developments in the field. Contents of this volume include these 7 reviews: - Recent advances in copper-catalyzed heterocyclic syntheses - Application of modern green chemistry methods in the synthesis of quinolines, quinazolines and quinazolinones - Electroluminescence polymers-a review on synthesis by organic compounds - Multicomponent approach for the synthesis of xanthenes - From atoms to macromolecules: 100 years of polymer research - An overview of oxidizing and reducing agents in total synthesis - Amino acid-derived ionic liquids: novel biodegradable catalytic systems for green synthesis of heterocycles

The Evolution of Radionanotargeting towards Clinical Precision Oncology is a remarkable book honoring Professor Kalevi Kairemo, who is known among academic and medical circles as a pioneer in novel radiolabeled therapeutics. This festschrift provides an overview of key advances in the field of radionanotargeting, and the directions for future development in patient care. Prof Kairemo's research is based on multiomics, which involves multiple elements: genomics, transcriptomics, proteomics, metabolomics, microbiomics, epigenomics, exposome, imaging, and precision medicine, which is reflected by the unique collection of articles presented. The articles start from the angle of radionanotargeting and theragnostics leading to imaging and therapy, which includes sections for thyroid cancer, head and neck cancer, genitourinary cancers and neuroendocrine neoplasms. Theragnostics, nanoparticles and precision oncology have also been covered in their own segments, while also giving a glimpse of research in metabolic imaging, cardiovascular radionuclide imaging, and bone therapies. The sequence of chapters demonstrates how, through Professor Kairemo's efforts, radionanotargeting has evolved to a practice changing therapeutic approach in the clinic, particularly in oncology. Finally, Professor Kairemo's own memoir, Seven decades in health care and memoirs from colleagues including a personal introduction to him with a photographic cavalcade reveals the world of a multitasking person with a multidisciplinary approach to science, that ushered his development of significant expertise across the fields of chemistry, biology, engineering, physics and clinical medicine. This book is excellent for medical historians, trainees and specialists in clinical and radiological oncology in expanding their understanding of the role of radionuclide imaging over the years, making it an ideal tribute that belongs in the library of anyone involved in the field.

Hepatocellular carcinoma (HCC) is a leading cause of death globally. Conventional chemotherapeutic agents are unable to penetrate cancerous hepatocytes completely and are toxic to non cancerous cells and tissues. This toxicity significantly compromises the therapeutic outcome of conventional chemotherapeutic agents which is also reflected in the high mortality of the disease. Nanotherapeutics have shed new light onto HCC treatment by enabling site-specific in vivo delivery of chemotherapeutics specifically to neoplastic hepatocytes without affecting normal hepatocytes. Thus, nanotherapeutics have shown considerable potential and there is tremendous impetus for rapid translation from the pre-clinical to the clinical domain to significantly prolong the survival in HCC. In Nanotherapeutics for the Treatment of Hepatocellular Carcinoma, authoritative experts of the field have explored the important aspects of nanotherapeutics against HCC. The book exhaustively, vividly and explicitly describes the molecular pathogenesis, diagnostic aspects and nanotherapy of HCC, while also highlighting the challenges of conventional therapy and the benefits of nanotherapeutics. Chapters of the book also cover recent investigations of nanotherapeutics against HCC, types of nanomedicines, recent patents, commercially available nanotherapeutics and a future perspective to give a comprehensive review of the topic to readers. In addition to these defining features, the book provides several references for further reading. The book is an ideal resource on HCC nanotherapeutics for medical and pharmacology postgraduate students, faculties, researchers, and biomedical scientists working on HCC and nanotherapy.

This technical reference covers information about modern nanocatalysts and their applications in organic syntheses, electrochemistry and nanotechnology. The objective of this book is to present a review of the development of nanocatalysts in the fields of organic synthesis and electroanalysis over the last few decades. It provides readers comprehensive, systematic and updated information about the relevant topics. The reader is introduced to nanocatalysts, with the following chapters delving into the different chemical reactions in which they are involved. The topics covered include: carbon-carbon coupling reactions, aryl and organic carbon hetero atom coupling reactions, oxidation-reduction reactions, photocatalysis, heterocyclic reactions and multicomponent catalysis. The concluding chapters cover applications of nanocatalysts in electrochemical synthesis and sensing. The thirteen chapters demonstrate the value of a variety of catalysts that are important in chemical engineering processes. Advanced Nanocatalysis for Organic Synthesis and Electroanalysis delivers a quick and accessible reference on advanced nanocatalysis for a broad range of readers which includes graduate, postgraduate and Ph. D. students of chemical engineering as well as faculty members, research and development (R&D) personnel working in the industrial chemistry sector.

Advanced Physical Chemistry Practical Guide aims to improve the student’s understanding of theory through practical experience and by facilitating experimental exercises. The book covers a wide range of areas from basic to advanced experiments including the calibration of instruments as well as the use of software for accurate computational quantum chemical calculations. This book is divided into four sections: part I - general introduction, calibration of glassware, instruments and precautions part II - experiments that have a simple theoretical background and classical methods part III - experiments that are associated with more advanced theory, and technique that require a greater degree of experimental skill and instrumentation part IV – investigative experiments relying on computers Covering all aspects of classical, advanced and computational chemistry experiments, Advanced Physical Chemistry Practical Guide will enable students to gain confidence in their ability to perform a physical chemistry experiment and to appreciate the value of an experimental approach towards the subject. Advanced Physical Chemistry Practical Guide is an essential handbook for students and teachers at advanced levels who seek to learn practical knowledge about important aspects of physical chemistry.

Advanced Techniques of Analytical Chemistry explains analytical chemistry in an accessible manner for students. The book provides basic and practical knowledge that helps the learner to understand the methods used in conducting experiments. Readers will understand the key concepts of qualitative and quantitative analysis through easy-to-read chapters written for chemistry students. Volume 1 covers the topic of volumetric analysis in detail. Topic-wise chapters introduce the reader to volumetric titrations and then explain the range of titration techniques which include aqueous acid-base titration, non-aqueous titration, redox titration, complexometric titration and some miscellaneous methods like diazotisation titration, Kjeldahl’s method and the oxygen flask combustion method. The combination of basic and advanced methods makes this an ideal textbook for chemistry students at graduate and undergraduate levels as well as an ideal handbook for the laboratory instructor.