Current Gene Therapy

Volume 25, Issue 5 , 2025

Review Article

Implications of EBV-Encoded and EBV-Related miRNAs in Tumors

Pp: 567-585
Author(s): Prankur Awasthi, Arjun Singh Kohli, Manish Dwivedi and Saba Hasan*
DOI: 10.2174/0115665232327174241211075019
Published on: 08 January, 2025

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Review Article

Development of Lentiviral Packaging Cells and Scale Up of Production to Meet the Growing Demand in Cell and Gene Therapy

Pp: 586-598
Author(s): Yasemin van Heuvel and Jörn Stitz*
DOI: 10.2174/0115665232332412241118063211
Published on: 13 January, 2025

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Review Article

Exploring Genetic and Receptor-Based Dopaminergic Strategies for Antidepressant Drug Development

Pp: 599-626
Author(s): Arzoo Pannu* and Ramesh K. Goyal
DOI: 10.2174/0115665232334693250110175517
Published on: 21 January, 2025

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Review Article

Molecular Insights into RNA Modifications and Their Role in Shaping Immune Responses and Tumor Microenvironments

Pp: 627-645
Author(s): Ashiq Ali*, Tehreem Ajmal, Aisha Khatoon, Kaynaat Akbar, Urooj Irshad, Bilal Murtaza, Ziyi Ji, Abdullah Ali, Qaisar Tanveer and Zhongjing Su*
DOI: 10.2174/0115665232335322241205063758
Published on: 21 January, 2025

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Review Article

Untangling the Genetic Threads of Alzheimer's: Insights into Risk Factors and Biomarkers

Pp: 646-662
Author(s): Atabak Naiyeri, Amin Moqadami and Mohammad Khalaj-Kondori*
DOI: 10.2174/0115665232338503241227111640
Published on: 07 January, 2025

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Review Article

CRISPR/Cas System: A Powerful Strategy to Improve Monogenic Human Diseases as Therapeutic Delivery; Current Applications and Challenges

Pp: 663-692
Author(s): Fatemeh Saberi, Zeinab Yousefi-Najafabadi, Forough Shams*, Zeinab Dehghan, Sepideh Ahmadi, Tayyebeh Pilehchi, Effat Noori, Zeinab Esmaeelzadeh, Maryam Bazgiri, Rezvan Mohammadi, Farzaneh Khani, Marzieh Sameni, Parisa Moradbeigi, Gholam Ali Kardar, Mohammad Salehi, Yong Teng and Vahid Jajarmi*
DOI: 10.2174/0115665232345516241119070150
Published on: 07 January, 2025

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Review Article

Neurotrophins as Potential Gene Therapy Targets for Huntington's Disease

Pp: 693-702
Author(s): Sagor Kumar Roy*, Ashima Barman, Kumary Labone Sarkar, Seidu A. Richard and Bijal Arvinkumar Lacmane
DOI: 10.2174/0115665232348486241025084202
Published on: 01 January, 2025

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Research Article

Identification of Gene Signatures Associated with COVID-19 across Children, Adolescents, and Adults in the Nasopharynx and Peripheral Blood by Using a Machine Learning Approach

Pp: 703-717
Author(s): YuSheng Bao, JingXin Ren, Lei Chen, Wei Guo, KaiYan Feng, Tao Huang* and Yu-Dong Cai*
DOI: 10.2174/0115665232316769240912061652
Published on: 27 September, 2024

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Research Article

Plasmalogens Activate AKT/mTOR Signaling to Attenuate Reactive Oxygen Species Production in Spinal Cord Injury

Pp: 718-728
Author(s): Mengdan Cheng, Yan Gao, Yiqing Wu, Liangliang Zhang, Bai Xu* and Xiaojie Lu*
DOI: 10.2174/0115665232330349241225074627
Published on: 20 January, 2025

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Research Article

O-substituted Tertiary Amine-chitosans as Promising Nanocarriers for siRNA Delivery

Pp: 729-746
Author(s): Andre Miguel Martinez Junior, Vera Aparecida de Oliveira Tiera and Marcio Jose Tiera*
DOI: 10.2174/0115665232335957241122164034
Published on: 10 January, 2025

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Research Article

siRNA Knocking Down in HepG2 Cells Identifies PFKFB4 and HNF4α as Key Genes Important for Cancer Cell Survival

Pp: 747-760
Author(s): Amer Imraish*, Walhan Alshaer, Tuqa Abu-Thiab, Fatima Enaya, Hamzeh J. Al‐Ameer, Afnan Alhunaiti, Mohammad Abumurad and Malek Zihlif
DOI: 10.2174/0115665232337735250101121115
Published on: 17 January, 2025

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Research Article

Identification of the Metabolic Characteristic of Organ Fibrosis Using Microbial Analysis on RNA-seq Data

Pp: 761-773
Author(s): Zitong Wang, Ping Wang, Guoyou He, Liang Cheng, Tianyu Li*, Yan Wang* and Hong Li*
DOI: 10.2174/0115665232257596231011110813
Published on: 03 January, 2025

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Research Article

Expression of miR-92a in Green Tea EGCG Preconditioned Adiposederived Stem Cells Ameliorates Inflammatory Response and Increases Cartilage Regeneration in RA Rats through KLF4/IL-17/MMP-2 Axis Modulation

Pp: 774-785
Author(s): Tung-Sheng Chen*, Wei‐Wen Kuo and Chih-Yang Huang
DOI: 10.2174/0115665232339721250313075146
Published on: 03 April, 2025

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Research Article

The Antimicrobial Peptide Pipeline: A Bacteria-Centric AMP Predictor

Pp: 786-792
Author(s): Werner Pieter Veldsman, Zou Yuanjie, Qi Zhang, Qian Zhao and Lu Zhang*
DOI: 10.2174/0115665232343790250120071445
Published on: 26 February, 2025

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Research Article

Pan-Cancer Single-Cell Analysis Revealing the Heterogeneity of Cancer- Associated Fibroblasts in Skin Tumors

Pp: 793-821
Author(s): Yichi Zhang, Zhijie Zhao, Wenyi Huang, Byeong Seop Kim, Li Lin, Xin Li, Mengyuan Hou, Li Li, Yan Zhang*, Wenjing Xi* and Gang Chai*
DOI: 10.2174/0115665232331353240911080642
Published on: 25 September, 2024