This monograph focuses on the actions exerted by sex hormones, 17β-estradiol and testosterone, in skeletal muscle tissue. An important consideration of this volume is the fact that both estrogen receptors (ERs) and androgen receptors (ARs) are ubiquitously expressed and, as a result, steroid hormones affect growth and different cell functions in several organs. Moreover, ERs and ARs may have a non-classical pattern of intracellular localizations, raising complexity to the functional roles of estradiol and testosterone. </p><p> Readers will find key information about the role of sex hormones in mitochondrial physiology and their relation with ageing, apoptosis, and sarcopenia. Chapters integrate important points with the latest information on the subject, including work of leading researchers studying the cellular and molecular mechanisms underlying the age-linked changes in muscle tissue while highlighting the role of satellite cells. </p><p> Furthermore, the book presents a chapter about phytoestrogens (compounds which are structurally very similar to estrogen 17β-estradiol) and their selective action on sex steroid receptors (specifically, they have a higher affinity for ERβ receptors than ERα receptors). </p><p> The book is recommended reading for scientists and clinicians involved in the field of medical and health sciences as well as for scholarly readers (students of biochemistry and medicine) who are interested in the molecular mechanism of cellular apoptosis regulated by steroid hormones.

This eBook presents a summary of central aspects of sialobiology (i.e., the study of sialic acid and its relevance to biology). The importance of substitution by the sugar sialic acid and the role played by sialylated structures (eg. glycoproteins, glycolipids, glycoconjugates) in immune recognition, neural cell growth, embryogenesis and disease development including microbial pathogenesis and cancer progression, has become well-established. Since 1995, the field of sialobiology has expanded greatly as many of the key enzymes involved in sialic acid biosynthesis, as well as the vast majority of sialic acid binding lectins involved in immune recognition, have only been cloned, characterised and structural eluciated after the publication of earlier works on the subject. This e-book also covers these recent developments. Chapters in this e-book have been contributed by eminent sialobiologists. Therefore, a book of this nature is timely and will prove to be a definitive volume with a high impact in this field for glycobiologists and cell biologists.

Aromatherapy is a medical practice that uses aromatic compounds or essential oils to influence mood and health. Essential oils used in aromatherapy are created from a wide variety of medicinal plants, flowers, herbs, roots, and trees that are found all over the world and have significant, well-documented benefits on enhancing physical, emotional, and spiritual wellbeing. This book is a comprehensive reference on aromatic compounds present in essential oils and their therapeutic use. Starting from fundamentals of essential oil biosynthesis the book guides the reader through their basic biochemistry, toxicology, profiling, blending and clinical applications. The concluding chapters also present focused information about the therapeutic effects of essential oils on specific physiological systems, plant sources, skin treatment and cancer therapeutics. The combination of basic and applied knowledge will provide readers with all the necessary information for understanding how to develop preclinical formulations and standard clinical therapies with essential oils. This is an essential reference for anyone interested in aromatherapy and the science of essential oils.

This inter-disciplinary volume provides information on anticancer medicines derived from marine organisms. Eight edited reviews extensively list the variety of organisms including marine plants, sponges, cnidarians and fish. Emphasis is placed on the source of the compounds, their structure and mechanism of action. Anticancer peptides from sponges are covered in a dedicated chapter. The specific biology and ecology of marine organisms yielding these anticancer compounds is also highlighted where appropriate. All chapters include detailed references for advanced readers. This volume is a standard text-cum-reference for teachers, students and researchers of various disciplines such as Biomedical Sciences, Pharmaceutical Sciences, Marine Biology, and Fisheries Science, it also serves as a guide to marine anticancer compounds for professionals in the pharmaceutical industry who are involved in the development of new marine-derived anticancer drugs.

Practical Biochemistry provides both foundational knowledge and advanced insights into biochemistry, including the basic compounds, and laboratory methods. The book is designed for students and academic professionals seeking a comprehensive understanding of the practical aspects of the subject. The book is systematically divided into five sections, each dedicated to a specific category of macromolecules and related biochemical techniques: 1) Carbohydrates, 2) Proteins, 3) Nucleic acids, 4) Lipids, 5) Supplementary Techniques and Safety Data Sheet (SDS). Each chapter within these sections is structured to provide a thorough understanding of the aim, principles, procedures, and practical applications of biochemical techniques. Key features: . Comprehensive Information: meticulously organized and structured chapters provide a thorough and methodical approach to learning . Additional Learning Tools: 'Did You Know' segments and 'Viva Voice' questions enrich the learning experience by offering interesting facts and stimulating critical thinking . Practical Focus: Step-by-step guides aid readers in understanding and applying the techniques in the lab . Safety and Accuracy: teaches how to conduct safe and accurate experiments with precautions . Accessible Language: simple and lucid language helps beginners to understand complex biochemical concepts.

Mind Maps in Clinical Biochemistry is an essential test preparation guide aimed specifically at students studying clinical biochemistry as part of their medical, nursing, or biomedical science courses and for candidates preparing for postgraduate entrance and board examinations. The book presents a series of comprehensive case- based learning modules designed to address key teaching points in clinical biochemistry in the context of real clinical experience. Students can begin to understand routine clinical cases by reading biochemical results in the context of a clinical history, examination findings and other diagnostic information. The content also equips readers with the information to propose a differential diagnosis, a treatment plan and a prognosis at later stages. Key Features · Concept maps for basic and applied clinical biochemistry · Structured outline for clinical cases including history with lab findings, clinical correlations and clinical evaluation · Answers and explanations to facilitate learning · References for further reading · OSPE questions for self-assessment and exam preparation

This Ebook aims to review basic understandings and give current opinions about several important aspects of glycosylphosphatidylinositol-anchored (GPI) protein biology from leading experts in this exciting and emerging field. The scope ranges from micro-domain localization and signaling to proteomics aspects, biophysical behavior through trans-cellular mobility to chemical synthesis of GPI mimics and finally modification of multi-scaled membrane surfaces and potential medical and biotech uses. The applied slant makes it very useful to the current state of knowledge. It is hoped that it will prove to be of considerable interest to students and researchers in this field.

Glycosylation and Glycation in Health and Diseases provides a comprehensive exploration of the essential biochemical processes, their implications in physiology, and their role in disease progression. This book is divided into two key sections: the first focuses on glycosylation, an enzymatic process essential for cellular function, while the second covers glycation, a nonenzymatic reaction linked to aging and chronic diseases. It covers congenital glycosylation disorders, the biology of advanced glycation end products (AGEs), and the critical role of the receptor for AGEs (RAGE) in inflammatory, neurological, cardiovascular, and cancer-related conditions. A valuable resource for students, researchers, and industry professionals, this book highlights the significance of glycobiology in drug discovery, diagnostics, and therapeutic innovations. Key Features: - Covers fundamental and advanced concepts of glycosylation and glycation. - Discusses the role of glycans in cellular function and disease pathology. - Explores AGE-RAGE interactions in cardiovascular, pulmonary, and neurological disorders. - Highlights applications in biopharmaceuticals, diagnostics, and vaccine development.

A Journey Through Water: A Scientific Exploration of The Most Anomalous Liquid on Earth, is a monograph about water at molecular level. The monograph explores how its peculiar properties are related to its molecular structure. Readers are introduced to water through information about water in a wider perspective, properties of its liquid state, experimental techniques for molecular level investigations of liquid water, and computer simulation techniques. This is followed by chapters explaining the structural properties and principal applications of various phases of water (water as a normal liquid, supercooled water, ice and supercritical water). Key features of this reference include: - easy to understand, sequential and structured text making this reference ideal for readers with limited scientific knowledge of water physics - a list of institutions where water research is promoted in larger scales - 130 figures which supplement the text - an explanation of ten principal anomalies of water and associated theories The book is an excellent resource for novice researchers (physicists, chemists and chemical engineers) working on water and laymen who are interested in furthering their understanding of this precious liquid.

Advances in Mathematical Chemistry and Applications, Volume 1 highlights the emerging discipline of mathematical chemistry, or, more precisely, discrete mathematical chemistry. This volume is written by internationally renowned experts in the field. It comprises of a wise integration of mathematical and chemical concepts and covers numerous applications in the field of drug discovery, bioinformatics, chemoinformatics, computational biology and ecological health. The contents of this book include chapters on mathematical structural descriptors of molecules and biomolecules, topological representation of molecular structure, connectivity matrices, use of weighted 2D Fingerprints in similarity-based virtual screening and much more. This ebook is a valuable resource for MSc and PhD students, academic personnel and researchers seeking updated and critically important information on the fundamental concepts of mathematical chemistry and their applications.