Promising Cancer Therapeutic Drug Targets: Recent Advancements offers a comprehensive overview of novel and emerging strategies in cancer therapy. The book explores cutting-edge approaches such as exosomal delivery systems, CRISPR/Cas9 gene editing, and immunotoxins, alongside targeting mechanisms like cancer stem cells, apoptosis pathways, and key signaling processes. A strong emphasis is placed on the therapeutic potential of natural compounds in disrupting cancer progression and enhancing treatment response. Chapters are organized around molecular targets, therapeutic pathways, and bioactive agents to provide a clear, thematic structure. Key Features - In-depth exploration of CRISPR/Cas9, exosomes, and stem cell-targeted therapy - Focus on natural compounds in cancer treatment - Insights into key signaling pathways (Hippo, Hedgehog, STAT3) - Discussion on apoptosis and drug resistance mechanisms.

Spinal Surgery Biomechanics: Principles for Residents and Students provides a comprehensive overview of the biomechanical principles essential for understanding spinal surgery techniques. This book explores key topics, including pedicle screw anchorage, lumbar total disc replacement, interbody fusion techniques, and spinal surgery in osteoporotic patients. It also covers degenerative spondylolisthesis, interspinous devices, and spinal stability classification systems. Written for students, residents, and researchers, this volume simplifies complex biomechanical concepts with clear explanations, clinical insights, and up-to-date research findings. Key Features: - Covers essential biomechanics relevant to spinal surgery procedures. - Discusses surgical approaches, implant selection, and stability mechanisms. - Examines spine surgery in osteoporotic and degenerative conditions. - Explores motion-preserving and fusion-based spinal implants. - Reviews classification systems for spinal trauma and instability.

Introduction: Antibiotics and Reproductive Health explores the intricate interplay between antibiotics and the female reproductive system. This comprehensive volume offers an evidence-based analysis of how antibiotics impact fertility, pregnancy, and breastfeeding, with a special focus on antibiotic resistance and emerging treatment alternatives. Bridging medicine, pharmacology, and reproductive health, the book is structured into nine chapters covering topics from the mechanism of antibiotics in reproductive health to alternative therapies like probiotics and herbal medicine. It provides clinical guidelines and discusses risks such as antibiotic resistance and microbiome disruption. Key Features: - Detailed exploration of antibiotic mechanisms in reproductive health. - Discussion on risks including antibiotic resistance and hormonal effects. - Examination of alternative therapies like probiotics and herbal medicine. - Clinical guidelines for antibiotic use in reproductive health.

With renal dysfunction affecting millions worldwide, this book presents a timely and integrative look at emerging insights—from molecular foundations to clinical management. It explores the intricate mechanisms, systemic impact, and clinical complexities of kidney diseases in a multidisciplinary context. Spanning a broad spectrum of conditions, the book addresses renal tubular acidosis, polycystic kidney disease, renal lithiasis, diabetic kidney disease, and sodium imbalance–linked hypertension. Chapters delve into nephrotoxicity, loss of cellular identity in renal carcinoma, epigenetics, dysbiosis, and the evolving role of SGLT2 inhibitors. The book also highlights innovative approaches such as stem cell therapy and the systemic immune interactions that underlie chronic kidney injury. Key Features: Examines genetic and epigenetic underpinnings of renal disease Explores microbiota and immune system crosstalk in kidney pathology Discusses both acute and chronic conditions with clinical relevance Integrates foundational science with translational perspectives Includes emerging therapies and precision medicine approaches

Research Protocols for Ophthalmic Disease Mechanisms and Therapeutics: Glaucoma – Ocular Hypertension offers a detailed, step-by-step protocols for isolating, characterizing, and analyzing cells and tissues of the eye's anterior segment—where OHT originates—using techniques from molecular biology, pharmacology, and histology. Across eight thematic sections, the book covers ocular anatomy, drug screening, receptor localization, cell-based assays, in vitro and in vivo models, drug formulation, and cutting-edge technologies such as gene editing, single-cell RNA sequencing, and stem cell therapies. Each protocol is designed to support reproducibility and translational relevance. Key Features: Details validated protocols for drug discovery and disease modeling Demonstrates methods for studying receptor function and pharmacokinetics Provides animal models and ex vivo systems to evaluate therapeutic strategies Incorporates emerging tools such as CRISPR, metabolomics, and exosomes Bridges experimental design with clinical relevance for glaucoma research

Structured across four sections, the book begins with foundational models of practice, including MOHO, CMOP-E, PEO, and the Kawa model, before examining common and often underrepresented mental health conditions such as eating disorders and personality disorders. Building on this foundation, the book highlights occupational therapy–specific interventions, from psycho-education and CBT to sensory approaches and group work, offering practical tools and resources for clinicians. The final section critically discusses recovery, social determinants of mental health, participatory citizenship, and the role of technology in shaping future practice. Designed for flexible use, each chapter functions as a standalone resource, enabling readers to dip into specific topics as needed. Key Features Explains core occupational therapy models used in mental health practice. Addresses diverse conditions, including underrepresented diagnoses like eating and personality disorders. Demonstrates occupational therapy–specific interventions within interdisciplinary teams. Provides practice tools, instruments, and case-based examples for learners and professionals. Critiques recovery-oriented practice and explores emerging roles for technology and citizenship.

Herbal Nanotherapy for Diabetes merges the therapeutic potential of phytochemicals with advanced nano-delivery systems, the book highlights innovative strategies to improve bioavailability, ensure targeted delivery, and minimize side effects in diabetes therapy. Beginning with an overview of diabetes as a global metabolic disorder, the book outlines its challenges in conventional treatment and the limitations of herbal remedies in their raw form. It then transitions into the principles and methodologies of designing herbal nanoparticles, emphasizing formulation strategies, delivery mechanisms, and preclinical evaluations.Chapters also analyze clinical applications, therapeutic outcomes, and mechanisms of action, before culminating in future perspectives on nanotechnology-enabled herbal therapeutics for diabetes care. Key Features: Examines the challenges of conventional diabetes treatments and the role of herbal medicine. Explores the design, formulation, and development of herbal nanoparticles. Analyzes the mechanisms and therapeutic pathways of phytochemicals in diabetes care. Investigates nanotechnology-enabled strategies for targeted delivery and improved bioavailability. Assesses preclinical and clinical studies supporting the efficacy of herbal nanotherapy. Highlights future directions and innovations in herbal nanomedicine for diabetes management.

Ukot's Back to Basics MCQs: Pharmacology and Therapeutics, Parasitology, and Internal Medicine (Volume 2) is an invaluable revision resource for medical students, healthcare trainees, and professionals preparing for examinations in the clinical sciences. This volume expands the trusted Back to Basics series by focusing on three critical domains, pharmacology and therapeutics, parasitology, and internal medicine. The book begins with a series of MCQs in pharmacology and therapeutics, strengthening knowledge of drug mechanisms, interactions, and therapeutic applications. It then transitions to parasitology, offering essential coverage of parasite biology, transmission, and treatment. Internal medicine MCQs follow, emphasizing diagnostic reasoning and clinical decision-making across diverse medical specialties. Each section is reinforced with explanatory notes and references, ensuring not only exam preparedness but also conceptual clarity. Additional chapters on differential diagnoses and comprehensive references make this volume a complete self-study guide for learners and practitioners alike. Key Features: Presents MCQs across pharmacology and therapeutics, parasitology, and internal medicine with detailed answer notes. Reinforces critical concepts and promotes retention through structured question-answer formats. Strengthens diagnostic reasoning with a dedicated section on differential diagnoses. Provides comprehensive references for extended learning and evidence-based study. Supports exam readiness for medical students, healthcare trainees, and early-career clinicians.

Ukot's Back to Basics MCQs: Obstetrics and Gynecology (Volume 1) is a structured single-best-answer (SBA) multiple-choice book designed to strengthen core knowledge in obstetrics and gynecology. Each MCQ presents a stem with four options, guiding learners to identify the best possible answer, while the companion notes provide detailed explanations to reinforce key principles and clinical reasoning. The book covers essential topics in both obstetrics (including antenatal care, abnormal presentations, multiple pregnancy, labor complications, operative deliveries, hypertensive disorders, diabetes in pregnancy, hemorrhage, and the puerperium) and gynecology (including abnormal uterine bleeding, miscarriages, ectopic pregnancy, infertility, menstrual disorders, PCOS, STIs, contraception, fibroids, ovarian tumors, and cervical lesions). Supplementary chapters on differential diagnoses broaden clinical decision-making by addressing common and complex scenarios encountered in practice. Key Features: Presents SBA-format MCQs with clinically relevant stems and answers Provides detailed notes explaining reasoning, management, and guidelines Covers both obstetrics and gynecology comprehensively, from common to complex conditions Includes chapters on differential diagnoses to sharpen diagnostic skills Supports self-assessment, revision, and exam preparation in a practical format.

Ukot’s Back to Basics MCQs (Volume 3) expands the trusted series with a comprehensive collection of multiple-choice questions that sharpen clinical reasoning and reinforce essential concepts across three vital domains of medical practice: Mental Health, General Pediatrics, and Family Medicine. Designed for medical students, postgraduate trainees, and practicing clinicians, this volume combines exam-focused preparation with real-world applicability. The carefully structured chapters not only test knowledge but also strengthen diagnostic accuracy, therapeutic decision-making, and holistic patient management skills. Key Features Covers critical areas of psychiatry including anxiety, mood disorders, schizophrenia, substance use, psychotherapies, and geriatric psychiatry. Explores pediatric essentials from neonatal care and congenital conditions to malnutrition, infections, tumors, and cardiac disorders. Integrates principles of family medicine such as holistic care, ethics, genomics, health promotion, preventive strategies, and clinical audit. Strengthens exam readiness with detailed answers, explanatory notes, and differential diagnoses. Contains comprehensive index and bibliography for further study and clinical practice.