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DOI: 10.2174/97816080525611120101 eISBN: 978-1-60805-256-1, 2012 ISBN: 978-1-60805-520-3
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For Books Adit Ben-Baruch , " The Inflammatory Milieu of Tumors: Cytokines and Chemokines that Affect Tumor Growth and Metastasis ", Bentham Science Publishers (2012). https://doi.org/10.2174/97816080525611120101
Print ISBN978-1-60805-520-3
Online ISBN978-1-60805-256-1
Page: i-i (1) Author: Yinon Ben-Neirah DOI: 10.2174/97816080525611120101000i
Page: ii-iii (2) Author: Adit Ben-Baruch DOI: 10.2174/9781608052561112010100ii
Page: iv-vii (4) Author: Adit Ben-Baruch DOI: 10.2174/9781608052561112010100iv
Page: 3-13 (11) Author: Sivan Izraely and Isaac P. Witz DOI: 10.2174/978160805256111201010003 PDF Price: $30
Page: 14-28 (15) Author: Paola Larghi, Chiara Porta, Elena Riboldi, Paola Allavena, Alberto Mantovani and Antonio Sica DOI: 10.2174/978160805256111201010014 PDF Price: $30
Page: 29-56 (28) Author: Loris Bertazza, Simone Mocellin, Mark DeWitte and Donato Nitti DOI: 10.2174/978160805256111201010029 PDF Price: $30
Page: 57-80 (24) Author: Ron N. Apte and Elena Voronov DOI: 10.2174/978160805256111201010057 PDF Price: $30
Page: 81-87 (7) Author: Ellen C. Keeley, Borna Mehrad and Robert M. Strieter DOI: 10.2174/978160805256111201010081 PDF Price: $30
Page: 88-98 (11) Author: Yanchun Li and Amy M. Fulton DOI: 10.2174/978160805256111201010088 PDF Price: $30
Page: 99-114 (16) Author: Adit Ben-Baruch DOI: 10.2174/978160805256111201010099 PDF Price: $30
Page: 115-122 (8) Author: Amanda Burkhardt and Albert Zlotnik DOI: 10.2174/978160805256111201010115 PDF Price: $30
Page: 123-154 (32) Author: Dror Luger and Lalage M. Wakefield DOI: 10.2174/978160805256111201010123
Page: 155-167 (13) Author: Amnon Peled DOI: 10.2174/978160805256111201010155 PDF Price: $30
Page: 168-173 (6) Author: Adit Ben-Baruch DOI: 10.2174/978160805256111201010168
Tumor development and progression are multi-factorial processes, in which genomic alterations and modifications in gene expression in pre-malignant cells are joined by deleterious microenvironmental factors. The tumor microenvironment contains stroma cells and leukocytes, soluble factors and matrix components. The intensive interplay that exists between the host factors and the tumor cells plays a major role in dictating the final outcome of the malignant process. Inflammatory mediators are pivotal microenvironmental factors present in the tumor milieu. These inflammatory components support cell growth and invasion, induce mutagenesis, increase angiogenicity, and suppress potential anti-tumor immune functions. The inflammatory constituents that prevail in tumors include leukocytes and soluble mediators - cytokines and chemokines. This e-book describes the roles played by these mediators in malignancy, and explains the basis for their consideration as therapeutic targets in cancer. The e-book is a timely overview of the roles played by inflammatory soluble mediators in neoplastic diseases. The topics addressed in this volume serve as a handy reference to investigators studying basic aspects of the malignant tumor growth, to clinicians who wish to better understand the processes involved in malignancy, and to pharmacological professionals seeking novel candidates for therapeutic intervention in cancer.
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