A number of physical methods for drug penetration enhancement and improve bioavailability of the stratum corneum (SC) such as micro-needles, heating, iontophoresis, electroporation, and ultrasound have also been evaluated in the last decade. On the other hand, nanotechnology has shown remarkable potential in targetspecific delivery of drugs in the body. In this chapter, we discuss the role of overview about nanocarrier systems, physical enhancers and their possible combination in order to improve the passage of molecules through the organ systems. All these methods have their own advantages and disadvantages, nevertheless, novel developments are projected to be more adaptable to different needs.
Keywords: Controlled release, Drug delivery, Nanocarrier systems, Nanomedicine, Nanoparticles, Nanopharmaceutics, Physical penetration enhancers, Synergism, Therapeutic applications.