Recent studies on stem cells and protein interactions using proteomics
approaches have yielded novel perception on processes regulating development and
stem cell biology. The development of stem cell approaches has evolved in the postgenomic
era and the implementation of proteomic applications represents a great
challenge.
Understanding the mechanism that controls stem cell pluripotency, self-renewal and
differentiation will also improve the ability to develop stem cell-based therapies.
Current proteomics studies of stem cell signaling pathway can lead to the discovery of
molecular mechanisms that govern cell-cell interaction and/or with stem cell niche.
Stem cells represent an important potential therapeutical approach, both in regenerative
medicine and tumor pathology, allowing the understanding of the mechanisms that
underlie the biology of these cells.
Keywords: Cancer stem cells, Interactomics, Proteomics, Regenerative medicine,
Secretome, Signaling pathways, Stem cell biology, Stem cells therapy.
