Future direction of clear aligners could be directed at setting up protocols that can be used in complex malocclusion cases, especially for extraction and rotation of small teeth. Materials with more stable shape memory might be introduced that are capable of producing computer animated or planned tooth movement in real situation. The implementation of CBCT in diagnosis and communication with technicians is very important. However, this would entail proper knowledge of clear aligner companies’ technician to be more aware of CBCT, limitations of tooth movement and early communication with clear aligners’ prescribers. Again, utilization of TADs together with clear aligners can provide an alternative treatment to difficult cases that are currently not considered candidates for clear aligners.