Frontiers in Stem Cell and Regenerative Medicine Research

Volume: 2

Effect of Microenvironment Modulation on Stem Cell Therapy for Peripheral Nerve Injury

Author(s): Sufang Liu and Feng Tao

Pp: 190-224 (35)

DOI: 10.2174/9781681081830116020010

* (Excluding Mailing and Handling)


Previous studies have demonstrated that nerve damage results in rapid disruption of nerve function. Neural stem cells (NSCs) from spinal cord have been shown to promote peripheral nerve regeneration. However, the stem cell therapy still shows low efficiency in vivo and some miscommunications after nerve recovery. Our studies found that chemotactic factor stromal-cell derived factor 1α and hypoxia may improve the survival of the transplanted NSCs and their function. Here we discuss the effects of microenvironment on neural stem cell therapy for peripheral nerve injury and recent progresses in this research field.

Keywords: Hypoxia, microenvironment, Neural stem cells, neurotrophic factor, pain, Peripheral nerve injury, Stromal cell derived factor.

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