Frontiers in Stem Cell and Regenerative Medicine Research

Volume: 2

Differentiation Potential of Stem Cells into Ovarian Cells

Author(s): Derek Toms, Paul W. Dyce and Julang Li

Pp: 116-156 (41)

DOI: 10.2174/9781681081830116020007

* (Excluding Mailing and Handling)


The following chapter outlines the current research status of studies exploring the generation of two essential ovarian cell types from stem cells: meiotic female germ cells from primordial germ cells to oocytes; and supporting somatic granulosa cells that are necessary for correct germ cell development and sex hormone production. Recent studies have reported the generation of both cell types in vitro and in vivo from a variety of sources, including somatic stem cells, induced pluripotent stem cells, and embryonic stem cells. While significant progress has been demonstrated, there are many areas that require further investigation. This review also discusses current research limitations and future prospects of this field within the context of regenerative medicine.

Keywords: Differentiation, follicle, folliculogenesis, granulosa cell, meiosis, oocyte, ovary, stem cells.

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