Diabetes is a disease with widespread prevalence; it adversely affects human
health and contributes to the development of various chronic diseases, including
hypertension, adipose tissue dysfunction, cardiovascular and liver diseases, and diabetic
neuropathies and nephropathies. Diabetes is categorized as type 1 or type 2 diabetes. Type
1 is caused by autoimmune-mediated destruction of pancreatic β-cell islets, resulting in
insulin deficiency, whereas type 2 diabetes is characterized by insulin resistance and/or
abnormal insulin secretion. It is known that insulin resistance also leads to hypertension or
high blood pressure. Both diabetes and hypertension are risk factors for cardiovascular
disease and share a common pathophysiology, including insulin resistance, obesity,
inflammation, and oxidative stress. The use of phytochemicals to treat diabetes and
hypertension is of great interest. Curcumin is a biphenolic compound that has been used for
the treatment and prevention of diabetes and hypertension in traditional Ayurvedic
medicine. Dietary curcumin inhibits several cell signaling pathways known to be
dysregulated in diabetes and hypertension. In addition, it can prevent diabetes and
hypertension through antioxidant and anti-inflammatory mechanisms. Curcumin can
normalize sugar levels through the modulation of tumor necrosis factor α, free fatty acids,
nuclear factor κB (NF-κB), lipid peroxidation, and lysosomal enzymes. Furthermore, it
decreases thiobarbituric acid reactive substances and succinate dehydrogenase, while
activating peroxisome proliferator-activated receptor γ. Curcumin reduces insulin
resistance through the activation of lipoprotein lipase, NF-E2-related factor 2, and liver
enzymes participating in metabolic process. Thus, the interaction of curcumin with several
signal transduction pathways reverses insulin resistance, hyperglycemia, hyperlipidemia,
and other inflammatory symptoms associated with diabetes and hypertension.
Keywords: Curcumin, diabetes, hypertension.
