Owing to the evolution of resistant cells using standard antimicrobial methods, it
is necessary for us to find alternative strategies to block the attack without exerting
pressures on their duplicated structures and in some cases degradation of their Quorum
Sensing signals is suggested to be more efficient. In this chapter, we give a brief
introduction of quorum sensing basics. Then, we describe the computational approaches
that are used to find molecules to inhibit the chemical signals. After that, we present the
case studies using these computational methods. In one of the cases performed in E. coli
with the autoinducer molecule indole, we elaborate how to evaluate and find molecules
with the ability to degrade the indole. We present another case where biological molecules
with potential ability to degrade the autoinducer 3-OH-PAME Quorum Sensing system in
R. solanacearum were evaluated as potential quenchers.
Keywords: 3-OH-PAME, AHLs, autoinducer, bacterial signaling, biofilm,
Escherichia coli, indole, indole oxidase, lipase, molecular docking, molecular
dynamics, plant infection, Quorum quenching, Quorum sensing, Ralstonia
solanacearum.
