Frontiers in Medicinal Chemistry

Volume: 7

Vaccines against Cysticercosis: A Revisited Review Focusing on Taenia solium

Author(s): Edda Sciutto, Gladis Fragoso, Marisela Hernández, Gabriela Rosas, Carlos Larralde and Sergio Rosales-Mendoza

Pp: 313-335 (23)

DOI: 10.2174/9781608059706115070011


Taenia solium cysticercosis is a major parasitic disease that severely affects human health and the economy of undeveloped countries. Since pigs are obligate intermediate hosts, it is plausible to curb human transmission by reducing pig cysticercosis through effective vaccination. This article reviews the current knowledge on the development of vaccines against porcine cysticercosis. It highlights the development of plant-based, needle-free vaccine versions as a feasible and affordable approach to reduce the logistic costs of injectable vaccines, while preventing the digestive hydrolysis of vaccine antigens.

Keywords: Anti-cestodiasis vaccine, cestode prevention, cysticercosis, infectious diseases, multiepitope vaccines, neurocysticercosis, oral vaccination, poverty, recombinant vaccines, rural communities, S3Pvac, subcutaneous vaccination, synthetic vaccines, Taenia solium, transgenic plants, transmission control, transplantomic cells, TSOL18, vaccine delivery, vaccine field trial, vaccines.

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