Frontiers in Cardiovascular Drug Discovery

Volume: 2

Clinical Value of Catheter-Based Sympathetic Nerve Modulation

Author(s): A. Doltra, E. Fleck and S. Kelle

Pp: 231-248 (18)

Doi: 10.2174/9781608059683115020006

* (Excluding Mailing and Handling)


Hypertension is a prevalent condition leading to cardiovascular adverse events and mortality. Despite the pharmacologic treatments available, persistently elevated blood pressure can be observed in a significant number of patients. Dysfunction of the sympathetic nervous system plays an important role in hypertension. Radiofrequency ablation can disrupt the sympathetic innervation localized in the adventitia of the renal arteries, thus modulating the sympathetic nervous system. In this chapter sympathetic nerve modulation will be discussed, including physiopathological considerations, technical aspects and experience arising from animal and clinical studies.

Keywords: Animal models, arrhythmias, catheter-based, fibrosis, hyperinsulinemia, hypertension, hypertensive heart disease, hypertrophy, macroalbuminuria, metabolic syndrome, microalbuminuria, obstructive sleep apnea, pathophysiology, renal denervation, renal function, resistant hypertension, sympathetic hyperactivity, sympathetic nerve modulation, sympathetic nervous system, sympathetic overdrive.

Related Journals
Related Books
© 2023 Bentham Science Publishers | Privacy Policy