This chapter focuses on the relationship between alveolar ventilation and blood
perfusion in normal and diseased states. In particular, it explains the reasons for different
ventilation-perfusion ratios among lung regions. It explains the functional consequences of
pulmonary diseases that alter the ventilation-perfusion ratio, and demonstrates how
ventilation-perfusion abnormalities can be quantified. It describes in more detail the “three
compartment model” (equivalent of the real lung), the methods used to quantify the fraction
of pulmonary blood that does not undergo gas exchange (right-to-left blood shunt or venous
admixture) and those used for differentiating between the two major components of venous
admixture: maldistribution shunt-like effect and conductive (anatomical) shunt. The various
normal and abnormal conditions that result in venous admixture (right-to-left blood shunt)
are schematically represented, and the method for quantifying the fraction of alveolar
ventilation wasted in alveolar dead space is described. Finally, pros and cons of oxygen
therapy and potential complications of prolonged lung exposure to high O2 fractions, leading
to oxygen toxicity, are detailed.
Keywords: Alveolar Dead-Space, Alveolar Gas-Equation, Alveolar-Arterial
PO2-Gradient, Alveolar-Effective Gas, Alveolar-Ideal Gas, Blood R-lines,
Conductive-Shunt-Fraction, Gas R-lines, Hyperbaric-Oxygen Therapy,
Hypocapnic Bronchoconstriction, Hypoxic Vasoconstriction, Inert-Gas-Method,
Maldistribution-Shunt-Like-Effect, Oxygen Therapy, Oxygen Toxicity,
Physiological-Shunt-Fraction, Pulmonary Circulation, Shunt-Fraction Equation,
Three-Compartment-Model, Ventilation-Perfusion Distribution.
