End - stage kidney disease (ESKD) is characterized by deterioration of renal function, which ends fatally in uremia, and this is detected by multisystem manifestations. The present book evaluates the state of the science in end - stage kidney disease outcomes assessment and offers perspectives on what is required to advance the field. The chapters collectively cover a diverse set of topics, which are examined in a sequence suggested by the broad section heading below. Developed as stand - alone documents, the chapters can be read in any order. Each chapter presents a number of findings and the previews below provide only a favor of the full range of results.