Abstract
The 8H-thieno[2,3-b]pyrrolizinones, some of which exert very potent cytotoxic activity against tumor cell lines in vitro, are a promising novel series of anticancer agents. These compounds belong to the tripentone family and are based on 9Hpyrrolo[ 1,2-a]indol-9-one derivatives and their heterocyclic isosteres. This paper inventories the different synthetic strategies for tripentones and reviews their biological effects and therapeutic potential.
Keywords: Tripentone, pyrrolizinone, pyrroloindolone, thiophene, cancer, pyrrole , heterocycles, clauson-kaas, acylation, ring closure.
Related Journals
Current Chinese Science
Anti-Cancer Agents in Medicinal Chemistry
Current Computer-Aided Drug Design
Current Bioactive Compounds
Current Medicinal Chemistry
Current Topics in Chemistry
The Natural Products Journal
Current Catalysis
Current Chinese Chemistry
Combinatorial Chemistry & High Throughput Screening
Related Books
A Journey Through Water: A Scientific Exploration of The Most Anomalous Liquid on Earth
Advances in Mathematical Chemistry and Applications
Advances in Mathematical Chemistry and Applications
Advances in Mathematical Chemistry and Applications Volume 1 (Revised Edition)
Advances in Organic Synthesis
Advances in Organic Synthesis
Advances in Organic Synthesis
Advances in Organic Synthesis
Advances in Organic Synthesis
Advances in Organic Synthesis