We have built a model for gastric cancer predisposition caused by
hypergastrenimia during Helicobacter infection. The model was built using publically
available data form hypergastrenimic transgenic mice infected with Helicobacter. We
used the model to identify potential drug targets for gastric cancer, annexin II and
TRAF6, and to find prognostic biomarkers for gastric cancer predisposition due to
hypergastrenimia.
Keywords: Bioinformatics, pathway analysis, biomarkers, mechanistic model,
gastric cancer, stomach cancer, Helicobacter, gene expression microarray,
subnetwork enrichment analysis, NF-kappaB, annexin, gastrin, Pathway Studio.