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Chemoinformatics: Directions Toward Combating Neglected Diseases

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Chagas’ Disease

Author(s): Adriana de Oliveira Gomes, Alessandra Mendonça Teles de Souza, Alice Maria Rolim Bernardino, Helena Carla Castro and Carlos Rangel Rodrigues

Pp: 145-153 (9)

DOI: 10.2174/978160805183011201010145

* (Excluding Mailing and Handling)

Abstract

Chagas disease (American trypanosomiasis) is one of the most important parasitic diseases with serious social and economic impacts mainly in Latin America. Therefore Chagas’ disease treatment is still a challenge, mainly in Brazil, where the only commercially available drug is benznidazole (Rochagan®). Since 1984, the WHO has recommended the use of crystal violet (gentian violet) in blood banks in endemic areas to prevent transmission by transfusion.

Keywords: QSAR-3D, CoMFA, Chaga´s Disease.

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