The aim of this paper is to compile and examine regional NAMEA tables for the Greek economy and for the year 2005. The five main regions of Greece have been determined in accordance with the National Strategic Reference Framework (NSRF) approved by the European Commission for the period 2007-2013.The present work utilizes basic data on air emissions derived from the Greek Ministry of the Environment, Physical Planning and Public Works. The economic data are from the 2005 Input-Output regional tables for the Greek economy produced by the National Statistical Service of Greece, the Greek Academy and the single NAMEA Table for 2005. The derived regional NAMEA tables are a valuable tool for examining regional variations by using a series of environmental-economic indices such as the direct emission intensity coefficient, the direct and indirect emission intensity coefficients and each emission factor intensity on each component of final demand of the Greek economy. The paper also aims to establish in which regions there is an accumulation of emissions (particularly CO2) so that an anti-pollution policy can be formulated along with possible policies for substituting polluting production methods.