Alzheimer’s Disease (AD) is a progressive neurodegenerative condition that
primarily impairs memory, cognition, and behavioural functions. Since no definitive
cure currently exists, increasing attention has shifted toward lifestyle interventions and
nutraceutical supplementation as supportive strategies for prevention and symptom
management. Nutraceuticals such as polyphenols, omega-3 fatty acids, antioxidants,
and vitamins have shown promise in alleviating oxidative stress, neuronal
inflammation, and age-related neurodegeneration processes strongly implicated in AD
pathology. Compounds like curcumin, resveratrol, and docosahexaenoic acid (DHA)
have demonstrated neuroprotective properties in preclinical and clinical studies,
suggesting their potential in moderating cognitive decline and supporting brain health.
Lifestyle-based approaches, including regular physical activity, cognitive exercises,
and dietary modifications, further enhance protective outcomes. Exercise promotes
neuroplasticity, optimises cognitive performance, and reduces dementia risk, while
social engagement and mental stimulation strengthen resilience to cognitive
impairment. Nutritional patterns such as the Mediterranean diet, rich in plant-based
foods and healthy fats, are associated with a reduced risk of developing AD,
highlighting the significant role of diet in maintaining neural function. Although
ongoing research continues to explore optimal doses, duration, and mechanisms of
these approaches, integrating nutraceuticals with lifestyle modifications offers a
practical and holistic strategy to delay or minimise AD progression and improve
quality of life in at-risk individuals.
Keywords: Alzheimer’s disease, Antioxidants, Cognition, Exercise, Mediterranean diet, Nutraceuticals.
