An autoimmune response is the core cause of alopecia areata, which is a
disorder that causes hair loss and is influenced by a variety of different variables. It is
hypothesized that genetic predisposition and lifestyle-related environmental stressors,
such as physical and emotional stress, contribute to the development of the disorder.
Although the specific immunological processes are not yet entirely known, many
people consider that these elements play a role in the disease's progression. Current
medications may be utilized for therapy, yet these treatments lack curative efficacy,
and their employment is restricted due to probable harmful effects, particularly in
particular extreme scenarios. Consequently, scientific investigation is undertaken to
stress the development and production of new medicinal substances that are both safe
and free of undesired repercussions. Secondary metabolites are a vast spectrum of
natural compounds found in plants and microbes that have diverse bioactivities. The
present demand for plant drug discovery research shows the huge, undiscovered
pharmacological potential of secondary metabolites created by plants. Throughout
history, a vast variety of plant secondary products have been gathered from ancient
civilizations to effectively cure different maladies, owing to their original
pharmacological characteristics. This chapter addresses the history, treatment choices,
and anticipated applications of plant secondary metabolites in the construction of a
curative medicine for alopecia areata.
Keywords: Alopecia areata, Flavonoids, Hair follicle dynamics, Immunomodulatory effects, Secondary plant metabolites, Terpenoids.
