This chapter provides a comprehensive review of the mechanism underlying liposome formation, with a focus on the kinetic and thermodynamic factors
that drive the process. It explores various pathways, such as lipid transfer into an
aqueous medium and the formation of liposomes from pre-existing bilayers, while
also examining the influence of kinetic parameters on the final structure. A thorough
understanding of these mechanisms is essential for optimizing liposome size, stability,
and drug release properties, ultimately enhancing their efficacy in applications such as
drug delivery, diagnostics, cosmetics, and food science.
Keywords: Liposome formation, bilayer deformation, bending energy, line tension, critical radius.
