This chapter provides a complete overview of traditional (or conventional
or classical) liposome preparation methods, including their concepts, benefits, and
limits. It explains the fundamental procedures, such as thin-film hydration, solvent
injection, and emulsification, required to produce liposomes with specified sizes,
lamellarity, and encapsulation efficiencies. Furthermore, the chapter establishes the
framework for comprehending advanced and unique approaches addressed in later
chapters, making it an invaluable resource for new and seasoned liposome researchers.
Keywords: Liposome preparation, thin-film hydration, solvent injection, emulsification, encapsulation efficiency, lipid bilayer.
