Recent years have seen tremendous advancements in the treatment of
malignant brain tumors with systemic chemotherapy, providing fresh hope for better
patient outcomes. The innovative chemotherapeutic drugs, targeted treatments, and
combination regimens that have shown improved effectiveness and safety profiles are
the main topics of this chapter's exploration of these state-of-the-art developments. The
advent of blood-brain barrier-penetrant medications, customized treatment techniques
based on genetic and molecular tumor characterization, and novel delivery systems
including nanocarriers and convection-enhanced delivery are notable advances.
Moreover, combining immunotherapy with conventional chemotherapy is emphasized
as a possible way to beat tumor resistance and enhance treatment results. The chapter
also explores ways to improve medication penetration via the blood-brain barrier and
the processes underlying drug resistance. This chapter provides a thorough
understanding of how these developments are changing the therapy landscape for
malignant brain tumors through an extensive discussion of current clinical trials and
forthcoming research. The chapter offers insights into prospective new paradigms in
brain tumor care as well as future research initiatives by analyzing the incorporation of
these innovative medicines into clinical practice. This summary of the most recent
developments highlights how systemic chemotherapy may have a significant effect on
the prognosis and quality of life of patients with malignant brain tumors, opening the
door to more efficient and customized treatment approaches.
Keywords: Blood-brain barrier, Malignant brain tumors, Nanocarriers, Personalized medicine, Systemic chemotherapy, Targeted therapy.
