Spirooxindoles are a class of organic compounds characterized by a
spirocyclic framework, where an oxindole moiety (which is a structure containing an
indole fused to a carbonyl group) is connected to another ring system via a spiro carbon
atom. These compounds have attracted significant interest in medicinal chemistry due
to their diverse biological activities. They have been studied for their potential as anticancer, anti-inflammatory, and antimicrobial agents. The structural diversity of
spirooxindoles allows for a wide range of pharmacological activities, making them
valuable scaffolds in drug design. This chapter compiles the recent synthetic schemes
on asymmetric synthesis of spirooxindoles and their significance as potential drug
candidates. It discusses the different synthetic routes used to prepare chiral
spirooxindoles and highlights the impact of chirality on their biological activities.
Keywords: Asymmetric synthesis, Biological activities, Chiral, Medicinal chemistry, Spirooxindoles.
