Solid-Phase Organic Synthesis (SPOS) has gained prominence after the
pioneering work of Merrifield for the development of peptide synthesis using solidphase catalysis was published in the 1960s. Since then, chemists have shown
tremendous interest in expanding this field to develop environment-friendly, costeffective, and sustainable protocols for synthesizing diverse compounds used in
material synthesis. The major emphasis of solid base synthesis is on the growth and
emergence of sustainable and green chemistry. This approach largely relies on
converting solution-phase reactions into solid-phase processes. Key green chemistry
principles that support solid-phase synthesis include reduced use of toxic solvents,
fewer reaction steps, improved energy efficiency, and high atom economy. However,
the solid-phase approach has high efficiency, excellent selectivity, easy work-up, and
good dispersion of active reagent sites. Solid-supported basic catalysis has advanced
significantly over the last few decades, and it is widely used in the synthesis of organic
molecules, bench-top catalysts, and fine chemicals. An overview of solid basic
catalysts and their application in the synthesis of important organic molecules was
disclosed in this chapter. The initial section discussed the importance and synthesis of a
variety of supported solid base catalysts. The second part discusses the application of
solid base catalysts in various organic reactions and evaluates their catalytic
performance.
Keywords: Aldol condensation, Coupling reactions, Hydrogenation, Knoevenagel condensation, Michael addition, Solid-supported catalyst.
