Solid base catalysis has emerged as a promising strategy for driving
Multicomponent Reactions (MCRs) in organic synthesis. MCRs, involving more than
two starting reagents, occur under specific reaction conditions, yielding a single
product embodying key features of the starting materials. These reactions play a crucial
role in modern drug discovery, offering a rich origin of molecular variation and
enabling quick, automatic, and scalable production of organic molecules. Solid base
catalysts can facilitate various reactions, including condensation, rearrangement, and
hydrogenation, making them valuable across different industries. This chapter provides
a comprehensive overview of recent trends in solid base-catalyzed MCRs for ecocompatible heterocyclic synthesis, emphasizing their potential to advance
environmentally conscious and highly effective synthetic methodologies in organic
chemistry.
Keywords: Catalysis, Heterocycle, Multicomponent reactions, Solid base catalyst.
