Metabolic disturbances, chronic low-grade inflammation, and oxidative
stress serve as a pivotal nexus in the manifestation and progression of PCOS. In
essence, nutritional supplements have shown promising results in the restoration of
reproductive, metabolic, and psychological aberrations, in part in PCOS, by altering the
above-mentioned key pathways associated with PCOS etiology. Besides, deficiencies
in certain nutrients among PCOS women reinforce the notion that supplementation may
address imbalances to improve clinical symptoms, thus offering a strategic approach
towards comprehensive and personalized therapeutic interventions in relation to the
severity of manifestations of this endocrinopathy among women. This chapter aims to
elucidate empirical evidence supporting the application of prebiotics, probiotics,
synbiotics, vitamin D, vitamin B12, and vitamin K in the context of PCOS intervention.
Keywords: IR (Insulin resistance), Low-grade inflammation, Prebiotics, Probiotics, SCFA (Short Chain Fatty Acids), TMA (Trimethylamine), Vitamin K, Vitamin D, Vitamin B12.
