Accumulating data indicates that the pathophysiology of PCOS may involve
modified developmental and epigenetic programming brought on by hormonal
dysregulation of the mother's uterine environment. In addition, there is a higher chance
of PCOS-related metabolic and reproductive problems for both male and female
relatives of PCOS-affected individuals. This review aims to provide an overview of the
main research findings in the field of epigenetics and its influence on the manifestation
of this disorder in women. The major focus will be DNA methylation studies, the role
of miRNAs, and the transgenerational inheritance of PCOS.
Keywords: Androgen-secreting tumors, Cushing’s syndrome, Hypothyroidism, Hyperprolactinemia, Non-classic congenital adrenal hyperplasia.
