This chapter comprises the neurological pathogenesis of Coronaviridae in
the central nervous system (CNS). These viruses manifest their virulence factors
involving multiple organs of the body, initiating from febrile conditions, respiratory
distress, and hypoproteinemia leading to edematous fluid accumulation. They pave
their path to CNS by directly affecting the cranial plus vagus nerve fibers and synapses
or through systematic circulation. The viruses can have an affinity with various
receptor sites present on organs that help in hematogenous and retrograde mobility
towards CNS. Comorbidities occur excessively due to these viruses in the living system
involving vital organs such as the liver, heart, and lungs. Neurological dissemination of
these viruses is characterized by a permanent loss of nerves or part of the CNS, either
entirely or partially. Prevention is suggested, accompanied by adequate treatment and
care management to avoid extensive spreading of the virus throughout CNS.
Keywords: Comorbidities, MERS-COV, Neurological complications, SARS COV-2, SARS-COV.
