Proteins are the functional units of the cell that allow viruses to reproduce
inside host cells. Proteins are essential for a cell's proper operation. Gene variations can
reveal potential new therapeutic targets. Examining the innate immune system,
coagulation, and other host proteins about the severity or mortality of COVID-19
reveals potentially changeable maladaptive host responses. Proteins are considered to
be the high prevalent biological group of pharmacological factors, and high-throughput
proteomics methods are quickly being employed to find prospective target molecules
for innovative development of new drugs and repurposing studies. Researching the
naturally occurring variations in the human gene sequence that code for therapeutic
targets can also show how treatments work and ensure that people are safe. Researchers
can create novel or repurposed therapeutics by examining the host protein’s genetic
makeup that interacts with SARS-CoV-2 or supports host responses to COVID-19.
Keywords: COVID-19, RNA viruses, Ritonavir, Nucleocapsid, Spike proteins.
