Genetic Diversity of Coronaviruses: From SARSCoV to SARS-CoV-2 – (Part 2)

Newly Emerging Variants of SARS-CoV-2

Author(s): Muhammad Safdar*, Mehmet Ozaslan, Yasmeen Junejo, Umair Younas, Muhammad Zia Ahmad, Jannat Bibi and Sobia Noreen

Pp: 105-116 (12)

DOI: 10.2174/9789815322194125010008

* (Excluding Mailing and Handling)

Abstract

Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) virus appeared at the end of 2019 and was subsequently named coronavirus disease-19 (COVID-19). Its worldwide emergence resulted in a large number of infections. Many studies depicted that the information about genomic variations in viruses has important effects on the prognosis and treatment of transmissible diseases. In this chapter, we collected various genomic variants, performed a phylogenetic analysis of recently registered genomes at various databases, and characterized the SARS-CoV-2 operating on silicon tools. Many complete sets of SARS-COV-2 are available in different databases such as GenBank and verified by National Genomics Data Center (NGDC) and National Microbiology Data Center (NMDC) databases. We found various variants, and the most common variants were 3037C>T (ORF1ab), 14408C>T (ORF1ab), 23403A>G (S), 25563G>T (ORF3a), 1059C>T (ORF1ab) and 241C>T (5' UTR) in online data samples. In addition, the complete genome sequence identity of the SARS-COV-2 results was 96.2% similar to that of a bat. These identified variations have increased the frequency of the spread of SARS-CoV-2. This information assists a comprehensive collection that combines genomic characterization, epidemiological and graphical records


Keywords: Genomic variants, Phylogenetic analysis, SARS-COV-2, ORF3a , epidemiological records

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