Infections of the digestive system are responsible for many illnesses and
deaths in all ages worldwide. Conventional ways of producing vaccines have proven
inefficient at fighting these diseases, mainly because they cannot instigate mucosal
defenses, which are vital in protecting the entry points against pathogens. Mucosal
vaccines, meant to stimulate immune reactions on the mucus membranes, may be more
effective in preventing gastrointestinal infections. The chapter gives a general idea of
the current state of mucosal vaccines in gastrointestinal infections. First, we will
explore the different forms of gastrointestinal infections, including bacterial, viral, and
parasitic, identifying their prevalence and how they impact public health. Furthermore,
we consider conventional vaccine strategies such as restricted elicitation of mucosal
immune response and antibiotic resistance strains. The major role of mucosal immunity
against gastrointestinal pathogens will be discussed. The chapter gives a general idea of
the current state of mucosal vaccines in gastrointestinal infections. First, we will
explore the different forms of gastrointestinal infections, including bacterial, viral, and
parasitic, identifying their prevalence and how they impact public health. Furthermore,
we consider conventional vaccine strategies such as restricted elicitation of mucosal
immune response and antibiotic resistance strains. The major role of mucosal immunity
against gastrointestinal pathogens will be discussed. Moreover, we have dealt with
problems such as vaccine manufacture and regulation by emphasizing the ongoing
research in this area. To finish, they are a better way to prevent gastrointestinal
infections by using the body’s defense mechanisms. Continuous investments in
mucosal vaccine development and fresh ideas are highly needed to effectively address
the worldwide burden of gastrointestinal ailments.
Keywords: Antibiotics, Gastrointestinal infection, Immunity, Pathogen, Mucosal vaccine, MALT, Secretory IgA.
