Plants have many medicinal properties, and they play a major role in drug
discovery nowadays. Lawsonia inermis is commonly known as Henna and has
numerous medicinal properties. Lawsonia inermis (Family: Lythraceae) contains
carbohydrates, phenolics, flavonoids, saponins, proteins, alkaloids, terpenoids,
quinones, coumarins, xanthones, fat, resin, and tannins. The pharmacological studies
showed that Lawsonia inermis has antibacterial, antifungal, antiparasitic, antioxidant,
hepatoprotective, central nervous, analgesic, anti-inflammatory, antipyretic, wound and
burn healing, immunomodulatory, antiurolithiatic, antidiabetic, hypolipidemic,
antiulcer, antidiarrhoeal, diuretic, anticancer, and many other pharmacological effects.
In silico studies play a major role in the drug designing process, and they make the
process of drug designing easier, more cost-effective, and less time consuming than in
vivo and in vitro processes. In the last century, the emergence of in silico tools has
improved the quality of healthcare studies by providing high-quality predictions. These
methods have also helped medical biotechnologists design various vaccines, such as
multi-epitope vaccines using reverse vaccinology and immunoinformatics methods,
among which some have shown promising results through in vitro , in vivo, and clinical
trial studies. Hepatitis is a worldwide disease caused by HBV, HBC virus, etc. By
finding protein-ligand interactions using software like AutoDock graphically, accurate
results for the binding sites can be obtained. Drug likeliness and ADMET properties
decide the nature of the leaves in their efficiency for the production of drugs. This
study will give a detailed report on the in silico analysis of Lawsonia inermis leaves
against the Hepatitis virus.
Keywords: AutoDock, ADMET property, Drug likeliness, Hepatitis B virus, In silico, Lawsonia inermis.
