Metabolites that originate from the human host and microbiota significantly
alter host physiology and metabolism, which is a key factor in disease susceptibility
and development. The gastrointestinal tract's gut microbiota, a community of bacteria,
produces vital signalling metabolites that are essential to the hosts' physiological wellbeing. However, disruptions in the production of these metabolites can result in a
variety of diseases, including cancer, neurological diseases, gastrointestinal disorders,
metabolic diseases, and cardiovascular diseases. The understanding of gut microbiota
metabolites, encompasses their various forms and mechanisms of action on targets.
Furthermore, we enumerate their physiological and pathologic roles in both health and
illness, including influencing the gut microbiota's composition and providing
nourishment. In order to fight microbial-driven disorders and promote health, this study
can be useful in understanding the roles of gut microbiota metabolites as it provides
suggestions for designing appropriate therapeutic options. Many of these metabolites
may be used in conjunction with intestinal microbiota dysbiosis as diagnostic
biomarkers to track disease states.
Keywords: Autoimmune disease, Cancer, Cardiovascular disease, Diabetes, Food interaction, Gut microbiota, Immune response, Metabolites, Metabolite profiling, Neurological disorders.
