The adaptive environment that is crucial to the host’s health is the
microbiome. Several research works have revealed that dysbiosis, or changes in the gut
microbiota of humans can have an involvement in the etiology of a number of
prevalent ailments, including diabetes, cancer, and neuropsychiatric disorders.
Nonetheless, recent findings indicate the potential for a gut-eye axis, in which gut
dysbiosis suggests a crucial role in the progression and development of an array of
ocular conditions, that include uveitis, diabetic retinopathy, glaucoma and age-related
macular degeneration. Current therapeutic strategies include probiotic and prebiotic
supplementation, which seems to be the most economical and practical way to avoid
ocular diseases and return the gut microbiome to a healthy state. In this chapter, we
discuss the present understanding of gut dysbiosis linked with the pathophysiology of
common eye disorders along with potential therapeutic implications for future
translational studies in this research area.
Keywords: Age-related macular degeneration, Bacteriophage Therapy, Diabetic Retinopathy, Dysbiosis, Fecal transplant, Glaucoma, Gut-Eye Axis, Keratitis, Microbial-derived metabolites, Ocular disease, Retinal artery occlusion.
