This chapter presents a theoretical perspective on the self that is not only essential for understanding the sufferings of clients but
also for reflecting upon our roles in the therapeutic process. In addition to psychological and social factors, neurobiological
factors are integrated into the discussion. My intent is to offer readers a conceptual framework for thinking biopsychosocially
about clients. The framework underscores empathic understanding as the basis for the choice of specific interventive modes and
techniques, and the centrality of a therapeutic relationship as the vehicle through which a new sense of self may emerge for
clients. Biographies of three well known individuals are used to illustrate concepts.