The Middle East respiratory syndrome (MERS-CoV) is a betacoronavirusborne acute viral illness. Since it first appeared in 2012, multiple cases of animal-t-
-human transmission of MERS-CoV have been observed, indicating that MERS-CoV
has the potential to cause a widespread epidemic. It has been detected in bronchial
samples from more than 27 countries, with approximately 2,505 reported cases and a
mortality rate of 36%. Genetic heterogeneity of MERS-CoV between different samples
may have paved the way for cross-species transmission and changes in the tropics
between species and within species. MERS-CoV has many evolutionary genomic
origins in spike protein, envelope protein, matrix, and non-structural proteins (nsps)
and mutates continuously. In this chapter, we highlighted the causes and significance of
mutation in the amino acid sequences of spike protein, envelop protein, matrix protein,
nucleocapsid protein, and snp. Among the most enduring obstacles in controlling
coronavirus disease is the evolution of the virus, which is influenced by genetic
diversity, mutation, and natural selection.
Keywords: Evolution, Epidemic, Human, MERS-CoV, Samples.