Miniaturized systems, known as implantable drug delivery systems, are used
to administer medicinal medicines to specific sites within the body. They are made of
biocompatible substances that enclose the drug payload and control its kinetics of
release, enabling sustained delivery. These systems provide a number of benefits by
avoiding the drawbacks of oral drugs and conventional injectable techniques, including
increased bioavailability, fewer systemic side effects, and improved patient adherence.
The key characteristics and elements of implanted drug delivery systems, such as the
drug reservoir, release mechanism, and sensing capabilities, are highlighted in this
chapter. It explores several implant design techniques that allow for exact control of
drug release rates, including micropumps, microelectromechanical systems, and
biodegradable polymers. Potential uses for implantable drug delivery systems (IDDSs)
include the management of chronic pain, hormone replacement therapy, the
management of cardiovascular diseases, and cancer. The challenges and considerations
to be taken into account when developing IDDSs, such as biocompatibility, device
integration, and long-term dependability, are also covered in this chapter. Furthermore,
it explores ongoing studies aiming at enhancing remote monitoring capabilities, drug
loading capacity, and device performance. By enabling accurate and localized
administration, IDDSs have the potential to revolutionize the field of targeted
treatments. These technologies have promising potential for enhancing the patient’s
quality of life, lowering healthcare costs, and improving treatment outcomes.
Keywords: Biocompatible materials, Chronic pain management, Cancer treatment, Implantable drug delivery systems, Microelectromechanical systems, Sustained drug release.