Mucoadhesive drug delivery systems have gained significant attention in the
field of pharmaceutical research due to their ability to enhance drug bioavailability,
prolong residence time, and improve therapeutic outcomes. This chapter provides a
comprehensive overview of mucoadhesive drug delivery systems, highlighting their
importance in overcoming various challenges associated with conventional drug
delivery. The chapter commences by elucidating the physiological and biochemical
aspects of mucosal surfaces, emphasizing the significance of mucoadhesion in
optimizing drug absorption and distribution. It explores the diverse applications of
mucoadhesive systems across different mucosal sites, including the buccal, nasal,
ocular, vaginal, and gastrointestinal mucosa. Additionally, the mechanisms underlying
mucoadhesion, such as hydrogen bonding, electrostatic interactions, and covalent
bonding, are thoroughly examined. The chapter delves into the various classes of
mucoadhesive polymers, such as natural, synthetic, and semi-synthetic polymers,
highlighting their distinct properties, applications, and evaluations. The chapter
addresses key considerations such as biocompatibility, safety, and regulatory aspects
associated with the development of mucoadhesive formulations. In conclusion, this
chapter serves as a valuable resource for researchers, scientists, and practitioners in the
field of drug delivery, offering a comprehensive understanding of mucoadhesive drug
delivery systems and their potential to revolutionize the delivery of therapeutic agents
across mucosal membranes.
Keywords: Mucoadhesive DDS, Mucus membranes, Mucoadhesion mechanism, Mucoadhesion theory, Mucoadhesive polymers, Patient compliance.
