Modern pharmaceutical research and development has evolved to rely
heavily on controlled drug delivery systems because they provide creative ways to
improve therapeutic results while reducing side effects. The underlying ideas and
justification for controlled drug delivery systems are covered in detail in this chapter.
Beginning with a discussion of the drawbacks of conventional drug delivery techniques
and the benefits of controlled release, the chapter explains the need for controlled drug
delivery systems in modern medicine. The requirements for the design and formulation
of controlled drug delivery systems have also been discussed in the chapter. The
concepts of controlled drug release, which cover a variety of mechanisms, including
diffusion, erosion, and osmosis, take up a sizeable section of the chapter. Additionally,
emphasis is put on the function that mathematical modeling plays in predicting and
optimizing drug release characteristics. It examines the wide spectrum of therapeutic
uses for controlled drug administration, such as the treatment of chronic pain, cancer,
diabetes, and other chronic disorders. The chapter also illuminates the future trends of
such drug delivery systems like nanotechnology, personalized medicines, and
advancements in medical devices. It also explores regulatory aspects and challenges
involved in the design and commercialization of these systems, placing emphasis on
the necessity of stringent quality control and safety evaluations. In conclusion, this
chapter is a useful resource for researchers, scientists, and medical experts who want to
understand underlying ideas and justifications of controlled drug delivery systems.
Keywords: Controlled drug delivery, Digital health, Drug release kinetics, Implantable devices, Nanoparticle-based delivery, Personalized medicine, Transdermal drug delivery.
