Ionic liquids (ILs) are exceptional solvents having melting points at or
below 100 0C. They are completely made up of ions, often consisting of an organic
cation and an inorganic or organic anion. ILs having chiral moiety are referred to as
chiral ionic liquids (CILs). Cations, anions, or both can be chiral in CILs. A CIL can
have chiral azolinium, imidazolium, ammonium, or pyridinium as its chiral cationic
component. Lactic acid, borate, or camphor sulfonate are some examples of the chiral
anion. CILs have recently been used in electrophoretic techniques in different forms,
such as chiral ligands, background electrolyte (BGE) additives, chiral selectors, and
chiral stationary phases for the separation of chiral compounds. As they integrate the
benefits of ILs and the features of a chiral moiety, they are thought to be particularly
fascinating in chiral investigation. Notably, the use of CILs as chiral selectors offers
advantages over other chiral selectors whose employment is typically constrained by a
few issues, such as high-temperature instability, high UV absorptivity, complex
synthetic methodologies, low solubility, and expensive nature. Therefore, it is crucial to
consider how CILs can be used as solvents and chiral selectors. In this chapter, the
diverse applications of chiral ionic liquids as stationary phases in electrophoretic
separations are discussed in detail.
Keywords: Chiral ionic liquids, Chirality, Chiral molecules, Chiral selectors, Electrophoretic separations, Stationary phases.
