The vertebral endplate is a critical component of the intervertebral disc, and
its dysfunction can lead to various spinal disorders and chronic back pain. The structure
and function of the vertebral endplate play an important role in disc nutrition,
biomechanical support, and waste removal. Endplate-related conditions and their
respective pathophysiologies may play a role in painful degeneration, fractures, and
Modic changes. This chapter summarizes current concepts of therapeutic strategies
with an emphasis on regenerative medicine application. It discusses using
mesenchymal stem cells, platelet-rich plasma, growth factors, and tissue engineering
approaches for endplate regeneration and repair. Diagnostic strategies for assessing
vertebral endplate disorders and palliative as well as regenerative treatment strategies
are discussed. The current evidence, ongoing research, and prospects in endplate-based
therapies are highlighted.
Keywords: Annulus fibrosus, Disc degeneration, Degenerative disc disease, Fusion, Herniation, Intervertebral disc, Nucleus pulposus, Spine.