Interplay Between Gut-microbiota and Neurodegeneration

Introduction: The body of scientific evidence linking the microbiome to many diseases has grown dramatically over the past several years; neurological diseases have also shown a similar tendency. As a result, the gut-brain axis theory as well as the notion that there could be a connection between the gut microbiome and several CNS-related disorders whose pathophysiology is still not known have both emerged.

Development: We look at the role played by gut microbiomes in the gut-brain axis as well as the neurological conditions neuromyelitis optica, Alzheimer's, amyotrophic lateral sclerosis, Parkinson's, and multiple sclerosis, where changes in the gut microbiota have been linked to human studies.

Conclusions: The amount of data connecting gut microbiota to different neurological illnesses has significantly increased. Today, there is no longer any doubt that the gut microbiota of the host influences brain function. This review assembles a sizable body of credible research that is essential in emphasizing the crucial role of microbiota colonization in neurodevelopment and how changes in microbiota dynamics might have an age-dependent effect on brain function.

Keywords: Gut microbiota, Neurodegenerative disorders, Oxidative stress.