Introduction: The body of scientific evidence linking the microbiome to
many diseases has grown dramatically over the past several years; neurological
diseases have also shown a similar tendency. As a result, the gut-brain axis theory as
well as the notion that there could be a connection between the gut microbiome and
several CNS-related disorders whose pathophysiology is still not known have both
emerged.
Development: We look at the role played by gut microbiomes in the gut-brain axis as
well as the neurological conditions neuromyelitis optica, Alzheimer's, amyotrophic
lateral sclerosis, Parkinson's, and multiple sclerosis, where changes in the gut
microbiota have been linked to human studies.
Conclusions: The amount of data connecting gut microbiota to different neurological
illnesses has significantly increased. Today, there is no longer any doubt that the gut
microbiota of the host influences brain function. This review assembles a sizable body
of credible research that is essential in emphasizing the crucial role of microbiota
colonization in neurodevelopment and how changes in microbiota dynamics might
have an age-dependent effect on brain function.
Keywords: Gut microbiota, Neurodegenerative disorders, Oxidative stress.