Etiology and pathogenesis of dementing illness is largely resolvable in terms of
consequences of an advancing age that promotes the actual progression as assessed by the sequential
development of lesions cardinal to the neuronal circuitry involvement. One might view the dynamics
of such sequences as a contributing role in the actual evolution of lesions that centrally manifest as
neuronal pathophysiology. It is only in terms beyond the actual neuropathologic lesions that an
endstage consequence is dominated by irreversible transforming features in the transport mechanics of
both injury and compensation of neuronal function.