Heterocyclic Anti-Inflammatory Agents: A Guide for Medicinal Chemists

Pyrazole and Pyrazoline Derivatives as Anti-Inflammatory agents

Author(s): Prabhjot Kaur, Urmila Berar and Neera Raghav *

Pp: 117-143 (27)

DOI: 10.2174/9789815223460124010009

* (Excluding Mailing and Handling)


Heterocyclic compounds have provided significant contributions to the field of medicinal chemistry. Pyrazole and pyrazoline are a class of five-membered two adjacent nitrogen-containing compounds that are integral parts of a large number of commercial anti-inflammatory drugs. After an initial introduction to inflammatory response, mechanism involved therein, the chapter compiles recent synthetic schemes along with in-vivo and in-vitro studies of pyrazole and pyrazoline derivative as antiinflammatory compounds on various established and recently recognized molecular targets. 

Keywords: Anti-inflammatory agents, COX-1, COX-2, LOX, Carrageen paw edema, Cathepsins, Pyrazole, Pyrazoline.

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